{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Unlu Y"],"funding":["Intramural NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS"],"pagination":["949-958"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11045162"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(5)"],"pubmed_abstract":["<h4>Objective</h4>We investigated how changes in 24-h respiratory exchange ratio (RER) and substrate oxidation during fasting versus an energy balance condition influence subsequent ad libitum food intake.<h4>Methods</h4>Forty-four healthy, weight-stable volunteers (30 male and 14 female; mean [SD], age 39.3 [11.0] years; BMI 31.7 [8.3] kg/m<sup>2</sup>) underwent 24-h energy expenditure measurements in a respiratory chamber during energy balance (50% carbohydrate, 30% fat, and 20% protein) and 24-h fasting. Immediately after each chamber stay, participants were allowed 24-h ad libitum food intake from computerized vending machines.<h4>Results</h4>Twenty-four-hour RER decreased by 9.4% (95% CI: -10.4% to -8.5%; p < 0.0001) during fasting compared to energy balance, reflecting a decrease in carbohydrate oxidation (mean [SD], -2.6 [0.8] MJ/day; p < 0.0001) and an increase in lipid oxidation (2.3 [0.9] MJ/day; p < 0.0001). Changes in 24-h RER and carbohydrate oxidation in response to fasting were correlated with the subsequent energy intake such that smaller decreases in fasting 24-h RER and carbohydrate oxidation, but not lipid oxidation, were associated with greater energy intake after fasting (r = 0.31, p = 0.04; r = 0.40, p = 0.007; and r = -0.27, p = 0.07, respectively).<h4>Conclusions</h4>Impaired metabolic flexibility to fasting, reflected by an inability to transition away from carbohydrate oxidation, is linked with increased energy intake."],"journal":["Obesity (Silver Spring, Md.)"],"pubmed_title":["Impaired metabolic flexibility to fasting is associated with increased ad libitum energy intake in healthy adults."],"pmcid":["PMC11045162"],"funding_grant_id":["DK069091‐12","ZIA DK069091","DK069091-12"],"pubmed_authors":["Cabeza De Baca T","Chang DC","Unlu Y","Krakoff J","Rodzevik TL","Walter M","Piaggi P","Stinson EJ"],"additional_accession":[]},"is_claimable":false,"name":"Impaired metabolic flexibility to fasting is associated with increased ad libitum energy intake in healthy adults.","description":"<h4>Objective</h4>We investigated how changes in 24-h respiratory exchange ratio (RER) and substrate oxidation during fasting versus an energy balance condition influence subsequent ad libitum food intake.<h4>Methods</h4>Forty-four healthy, weight-stable volunteers (30 male and 14 female; mean [SD], age 39.3 [11.0] years; BMI 31.7 [8.3] kg/m<sup>2</sup>) underwent 24-h energy expenditure measurements in a respiratory chamber during energy balance (50% carbohydrate, 30% fat, and 20% protein) and 24-h fasting. Immediately after each chamber stay, participants were allowed 24-h ad libitum food intake from computerized vending machines.<h4>Results</h4>Twenty-four-hour RER decreased by 9.4% (95% CI: -10.4% to -8.5%; p < 0.0001) during fasting compared to energy balance, reflecting a decrease in carbohydrate oxidation (mean [SD], -2.6 [0.8] MJ/day; p < 0.0001) and an increase in lipid oxidation (2.3 [0.9] MJ/day; p < 0.0001). Changes in 24-h RER and carbohydrate oxidation in response to fasting were correlated with the subsequent energy intake such that smaller decreases in fasting 24-h RER and carbohydrate oxidation, but not lipid oxidation, were associated with greater energy intake after fasting (r = 0.31, p = 0.04; r = 0.40, p = 0.007; and r = -0.27, p = 0.07, respectively).<h4>Conclusions</h4>Impaired metabolic flexibility to fasting, reflected by an inability to transition away from carbohydrate oxidation, is linked with increased energy intake.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T20:58:25.494Z","creation":"2025-07-13T03:04:42.842Z"},"accession":"S-EPMC11045162","cross_references":{"pubmed":["38650517"],"doi":["10.1002/oby.24011"]}}