{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Tao M"],"pubmed_abstract":["The aim was to investigate the relationship between polymorphisms of gene mutation loci and reproductive traits in local sheep breeds (Duolang Sheep) and introduced sheep breeds (Suffolk, Hu Sheep) in Xinjiang to provide new molecular markers for the selection and breeding of high fecundity sheep. The expression pattern of typing successful genes in sheep tissues was investigated by RT-qPCR technology, providing primary data for subsequent verification of gene function. The 26 mutation loci of <i>WWC2</i>, <i>ARHGEF9</i>, <i>SLK</i>, <i>GAB3</i>, and <i>FSHR</i> genes were typed using KASP. Association analyses were performed using SPSS 25.0, and the typing results showed that five genes with six loci, <i>WWC2</i> (g.14962207 C>T), <i>ARHGEF9</i> (g.48271079 C>A), <i>SLK</i> (g.27107842 T>"],"journal":["Frontiers in genetics"],"pagination":["1371872"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11045898"],"repository":["biostudies-literature"],"pubmed_title":["Association analysis of polymorphisms in <i>SLK</i>, <i>ARHGEF9</i>, <i>WWC2</i>, <i>GAB3,</i> and <i>FSHR</i> genes with reproductive traits in different sheep breeds."],"pmcid":["PMC11045898"],"pubmed_authors":["Tao M","Li Z","Liu M","Ma H","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Association analysis of polymorphisms in <i>SLK</i>, <i>ARHGEF9</i>, <i>WWC2</i>, <i>GAB3,</i> and <i>FSHR</i> genes with reproductive traits in different sheep breeds.","description":"The aim was to investigate the relationship between polymorphisms of gene mutation loci and reproductive traits in local sheep breeds (Duolang Sheep) and introduced sheep breeds (Suffolk, Hu Sheep) in Xinjiang to provide new molecular markers for the selection and breeding of high fecundity sheep. The expression pattern of typing successful genes in sheep tissues was investigated by RT-qPCR technology, providing primary data for subsequent verification of gene function. The 26 mutation loci of <i>WWC2</i>, <i>ARHGEF9</i>, <i>SLK</i>, <i>GAB3</i>, and <i>FSHR</i> genes were typed using KASP. Association analyses were performed using SPSS 25.0, and the typing results showed that five genes with six loci, <i>WWC2</i> (g.14962207 C>T), <i>ARHGEF9</i> (g.48271079 C>A), <i>SLK</i> (g.27107842 T>","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-04-08T18:31:46.259Z","creation":"2026-04-08T09:40:18.118Z"},"accession":"S-EPMC11045898","cross_references":{"pubmed":["38680425"],"doi":["10.3389/fgene.2024.1371872"]}}