{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Voss AJ"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","NIMH NIH HHS","NINDS NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health"],"pagination":["1339-1351"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11046429"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(8)"],"pubmed_abstract":["Extrinsic signaling between diverse cell types is crucial for nervous system development. Ligand binding is a key driver of developmental processes. Nevertheless, it remains a significant challenge to disentangle which and how extrinsic signals act cooperatively to affect changes in recipient cells. In the developing human brain, cortical progenitors transition from neurogenesis to gliogenesis in a stereotyped sequence that is in part influenced by extrinsic ligands. Here we used published transcriptomic data to identify and functionally test five ligand-receptor pairs that synergistically drive human astrogenesis. We validate the synergistic contributions of TGFβ2, NLGN1, TSLP, DKK1 and BMP4 ligands on astrocyte development in both hCOs and primary fetal tissue. We confirm that the cooper"],"journal":["Nature neuroscience"],"pubmed_title":["Identification of ligand-receptor pairs that drive human astrocyte development."],"pmcid":["PMC11046429"],"funding_grant_id":["R01NS123562","R01MH125956","R01 MH125956","R01 NS123562"],"pubmed_authors":["Sojka C","Hill EJ","Bhatia TN","Lanjewar SN","Voss AJ","Sampson MM","Sing A","King A","Spangle JM","Sloan SA"],"additional_accession":[]},"is_claimable":false,"name":"Identification of ligand-receptor pairs that drive human astrocyte development.","description":"Extrinsic signaling between diverse cell types is crucial for nervous system development. Ligand binding is a key driver of developmental processes. Nevertheless, it remains a significant challenge to disentangle which and how extrinsic signals act cooperatively to affect changes in recipient cells. In the developing human brain, cortical progenitors transition from neurogenesis to gliogenesis in a stereotyped sequence that is in part influenced by extrinsic ligands. Here we used published transcriptomic data to identify and functionally test five ligand-receptor pairs that synergistically drive human astrogenesis. We validate the synergistic contributions of TGFβ2, NLGN1, TSLP, DKK1 and BMP4 ligands on astrocyte development in both hCOs and primary fetal tissue. We confirm that the cooper","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-05-03T03:26:49.791Z","creation":"2026-04-07T18:47:31.801Z"},"accession":"S-EPMC11046429","cross_references":{"pubmed":["37460808"],"doi":["10.1038/s41593-023-01375-8"]}}