{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guevara-Flores A"],"funding":["Dirección General de Asuntos del Personal Académico (DGAPA) at Universidad Nacional Autónoma de México (UNAM)","Dirección General de Asuntos del Personal Académico (DGAPA) at Universidad Nacional Autónoma de México (UNAM)."],"pagination":["444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11047392"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["Peroxiredoxins (Prxs) and glutathione peroxidases (GPxs) are the main enzymes of the thiol-dependent antioxidant systems responsible for reducing the H<sub>2</sub>O<sub>2</sub> produced via aerobic metabolism or parasitic organisms by the host organism. These antioxidant systems maintain a proper redox state in cells. The cysticerci of <i>Taenia crassiceps</i> tolerate millimolar concentrations of this oxidant. To understand the role played by Prxs in this cestode, two genes for Prxs, identified in the genome of <i>Taenia solium</i> (<i>Ts</i>Prx1 and <i>Ts</i>Prx3), were cloned. The sequence of the proteins suggests that both isoforms belong to the class of typical Prxs 2-Cys. In addition, <i>Ts</i>Prx3 harbors a mitochondrial localization signal peptide and two motifs (-GGLG- and -YP-) a"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["A Physiological Approach to Explore How Thioredoxin-Glutathione Reductase (TGR) and Peroxiredoxin (Prx) Eliminate H<sub>2</sub>O<sub>2</sub> in Cysticerci of <i>Taenia</i>."],"pmcid":["PMC11047392"],"funding_grant_id":["IN215223"],"pubmed_authors":["Guevara-Flores A","Nava-Balderas G","Rendon JL","Vasquez-Lima C","de Jesus Martinez-Gonzalez J","Del Arenal Mena IP"],"additional_accession":[]},"is_claimable":false,"name":"A Physiological Approach to Explore How Thioredoxin-Glutathione Reductase (TGR) and Peroxiredoxin (Prx) Eliminate H<sub>2</sub>O<sub>2</sub> in Cysticerci of <i>Taenia</i>.","description":"Peroxiredoxins (Prxs) and glutathione peroxidases (GPxs) are the main enzymes of the thiol-dependent antioxidant systems responsible for reducing the H<sub>2</sub>O<sub>2</sub> produced via aerobic metabolism or parasitic organisms by the host organism. These antioxidant systems maintain a proper redox state in cells. The cysticerci of <i>Taenia crassiceps</i> tolerate millimolar concentrations of this oxidant. To understand the role played by Prxs in this cestode, two genes for Prxs, identified in the genome of <i>Taenia solium</i> (<i>Ts</i>Prx1 and <i>Ts</i>Prx3), were cloned. The sequence of the proteins suggests that both isoforms belong to the class of typical Prxs 2-Cys. In addition, <i>Ts</i>Prx3 harbors a mitochondrial localization signal peptide and two motifs (-GGLG- and -YP-) a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-04-24T03:16:48.56Z","creation":"2026-04-24T03:09:46.093Z"},"accession":"S-EPMC11047392","cross_references":{"pubmed":["38671892"],"doi":["10.3390/antiox13040444"]}}