biostudies-literatureGuevara-Flores ADirección General de Asuntos del Personal Académico (DGAPA) at Universidad Nacional Autónoma de México (UNAM)Dirección General de Asuntos del Personal Académico (DGAPA) at Universidad Nacional Autónoma de México (UNAM).444https://www.ebi.ac.uk/biostudies/studies/S-EPMC11047392biostudies-literatureUnknown13(4)Peroxiredoxins (Prxs) and glutathione peroxidases (GPxs) are the main enzymes of the thiol-dependent antioxidant systems responsible for reducing the H₂O₂ produced via aerobic metabolism or parasitic organisms by the host organism. These antioxidant systems maintain a proper redox state in cells. The cysticerci of <i>Taenia crassiceps</i> tolerate millimolar concentrations of this oxidant. To understand the role played by Prxs in this cestode, two genes for Prxs, identified in the genome of <i>Taenia solium</i> (<i>Ts</i>Prx1 and <i>Ts</i>Prx3), were cloned. The sequence of the proteins suggests that both isoforms belong to the class of typical Prxs 2-Cys. In addition, <i>Ts</i>Prx3 harbors a mitochondrial localization signal peptide and two motifs (-GGLG- and -YP-) aAntioxidants (Basel, Switzerland)A Physiological Approach to Explore How Thioredoxin-Glutathione Reductase (TGR) and Peroxiredoxin (Prx) Eliminate H₂O₂ in Cysticerci of <i>Taenia</i>.PMC11047392IN215223Guevara-Flores ANava-Balderas GRendon JLVasquez-Lima Cde Jesus Martinez-Gonzalez JDel Arenal Mena IPfalseA Physiological Approach to Explore How Thioredoxin-Glutathione Reductase (TGR) and Peroxiredoxin (Prx) Eliminate H₂O₂ in Cysticerci of <i>Taenia</i>.Peroxiredoxins (Prxs) and glutathione peroxidases (GPxs) are the main enzymes of the thiol-dependent antioxidant systems responsible for reducing the H₂O₂ produced via aerobic metabolism or parasitic organisms by the host organism. These antioxidant systems maintain a proper redox state in cells. The cysticerci of <i>Taenia crassiceps</i> tolerate millimolar concentrations of this oxidant. To understand the role played by Prxs in this cestode, two genes for Prxs, identified in the genome of <i>Taenia solium</i> (<i>Ts</i>Prx1 and <i>Ts</i>Prx3), were cloned. The sequence of the proteins suggests that both isoforms belong to the class of typical Prxs 2-Cys. In addition, <i>Ts</i>Prx3 harbors a mitochondrial localization signal peptide and two motifs (-GGLG- and -YP-) a2024-01-01T00:00:00Z2024 Apr2026-04-24T03:16:48.56Z2026-04-24T03:09:46.093ZS-EPMC110473923867189210.3390/antiox13040444