{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi S"],"funding":["Ministry of Education","incheon national university"],"pagination":["447"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11047712"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["The glutamine-histidine-glycine-valine (QHGV), a peptide derived from oysters, exhibits antioxidant activity and is being actively researched as a potential pharmaceutical and functional cosmetic ingredient. In this study, we synthesized the QHGV peptide and explored the hitherto unknown anti-inflammatory effects of QHGV. The antioxidant property was also characterized by conjugating with various naturally derived phenolic acids, such as caffeic, gallic, ferulic, sinapinic, and vanillic acids. Conjugation with phenolic acids not only enhanced the antioxidant activity of QHGV but also diminished the lipopolysaccharide-induced generation of reactive oxygen species (ROS) in the murine macrophage cell line, RAW 264.7. The reduction in the levels of reactive oxygen species led to the reduced mR"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Synergistic Antioxidant and Anti-Inflammatory Effects of Phenolic Acid-Conjugated Glutamine-Histidine-Glycine-Valine (QHGV) Peptides Derived from Oysters (<i>Crassostrea talienwhanensis</i>)."],"pmcid":["PMC11047712"],"funding_grant_id":["NRF-2017R1A6A1A06015181","Research Assistance Program (2020)"],"pubmed_authors":["Choi S","Lee S","Kim J","Han S","Kang DK"],"additional_accession":[]},"is_claimable":false,"name":"Synergistic Antioxidant and Anti-Inflammatory Effects of Phenolic Acid-Conjugated Glutamine-Histidine-Glycine-Valine (QHGV) Peptides Derived from Oysters (<i>Crassostrea talienwhanensis</i>).","description":"The glutamine-histidine-glycine-valine (QHGV), a peptide derived from oysters, exhibits antioxidant activity and is being actively researched as a potential pharmaceutical and functional cosmetic ingredient. In this study, we synthesized the QHGV peptide and explored the hitherto unknown anti-inflammatory effects of QHGV. The antioxidant property was also characterized by conjugating with various naturally derived phenolic acids, such as caffeic, gallic, ferulic, sinapinic, and vanillic acids. Conjugation with phenolic acids not only enhanced the antioxidant activity of QHGV but also diminished the lipopolysaccharide-induced generation of reactive oxygen species (ROS) in the murine macrophage cell line, RAW 264.7. The reduction in the levels of reactive oxygen species led to the reduced mR","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-04-25T03:29:15.959Z","creation":"2026-04-25T03:22:32.029Z"},"accession":"S-EPMC11047712","cross_references":{"pubmed":["38671896"],"doi":["10.3390/antiox13040447"]}}