{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yoon BW"],"funding":["National Research Foundation of Korea","Chung-Ang University Research Grant"],"pagination":["807"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11047998"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["Researchers have proposed a possible correlation between age-related macular degeneration (AMD) and inflammation or C-reactive protein (CRP) levels. We investigated the potential causal relationship between CRP levels and AMD. Single-nucleotide polymorphisms (SNPs) associated with CRP exposure were selected as the instrumental variables (IVs) with significance (<i>p</i> < 5 × 10<sup>-8</sup>) from the genome-wide association study (GWAS) meta-analysis data of Biobank Japan and the UK Biobank. GWAS data for AMD were obtained from 11 International AMD Genomics Consortium studies. An evaluation of causal estimates, utilizing the inverse-variance-weighted (IVW), weighted-median, MR-Egger, MR-Pleiotropy-Residual-Sum, and Outlier tests, was conducted in a two-sample Mendelian randomization (MR) "],"journal":["Biomedicines"],"pubmed_title":["Potential Causal Association between C-Reactive Protein Levels in Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study."],"pmcid":["PMC11047998"],"funding_grant_id":["2022","2022R1C1C1002929"],"pubmed_authors":["Yoon BW","Seo JH","Lee Y"],"additional_accession":[]},"is_claimable":false,"name":"Potential Causal Association between C-Reactive Protein Levels in Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study.","description":"Researchers have proposed a possible correlation between age-related macular degeneration (AMD) and inflammation or C-reactive protein (CRP) levels. We investigated the potential causal relationship between CRP levels and AMD. Single-nucleotide polymorphisms (SNPs) associated with CRP exposure were selected as the instrumental variables (IVs) with significance (<i>p</i> < 5 × 10<sup>-8</sup>) from the genome-wide association study (GWAS) meta-analysis data of Biobank Japan and the UK Biobank. GWAS data for AMD were obtained from 11 International AMD Genomics Consortium studies. An evaluation of causal estimates, utilizing the inverse-variance-weighted (IVW), weighted-median, MR-Egger, MR-Pleiotropy-Residual-Sum, and Outlier tests, was conducted in a two-sample Mendelian randomization (MR) ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-04-15T03:21:33.087Z","creation":"2026-04-15T03:15:14.747Z"},"accession":"S-EPMC11047998","cross_references":{"pubmed":["38672162"],"doi":["10.3390/biomedicines12040807"]}}