{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(4)"],"submitter":["Ponomarenko I"],"pubmed_abstract":["The purpose of this work was to find a link between the breast cancer (BC)-risk effects of sex hormone-binding globulin (SHBG)-associated polymorphisms and obesity. The study was conducted on a sample of 1498 women (358 BC; 1140 controls) who, depending on the presence/absence of obesity, were divided into two groups: obese (119 BC; 253 controls) and non-obese (239 BC; 887 controls). Genotyping of nine SHBG-associated single nucleotide polymorphisms (SNP)-rs17496332 <i>PRMT6</i>, rs780093 <i>GCKR</i>, rs10454142 <i>PPP1R21</i>, rs3779195 <i>BAIAP2L1</i>, rs440837 <i>ZBTB10</i>, rs7910927 <i>JMJD1C</i>, rs4149056 <i>SLCO1B1</i>, rs8023580 <i>NR2F2</i>, and rs12150660 <i>SHBG</i>-was executed, and the BC-risk impact of these loci was analyzed by logistic regression separately in each group o"],"journal":["Biomedicines"],"pagination":["818"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11048332"],"repository":["biostudies-literature"],"pubmed_title":["Obesity-Dependent Association of the rs10454142 <i>PPP1R21</i> with Breast Cancer."],"pmcid":["PMC11048332"],"pubmed_authors":["Pasenov K","Churnosov V","Churnosova M","Ponomarenko M","Sorokina I","Aristova I","Churnosov M","Reshetnikova Y","Reshetnikov E","Ponomarenko I"],"additional_accession":[]},"is_claimable":false,"name":"Obesity-Dependent Association of the rs10454142 <i>PPP1R21</i> with Breast Cancer.","description":"The purpose of this work was to find a link between the breast cancer (BC)-risk effects of sex hormone-binding globulin (SHBG)-associated polymorphisms and obesity. The study was conducted on a sample of 1498 women (358 BC; 1140 controls) who, depending on the presence/absence of obesity, were divided into two groups: obese (119 BC; 253 controls) and non-obese (239 BC; 887 controls). Genotyping of nine SHBG-associated single nucleotide polymorphisms (SNP)-rs17496332 <i>PRMT6</i>, rs780093 <i>GCKR</i>, rs10454142 <i>PPP1R21</i>, rs3779195 <i>BAIAP2L1</i>, rs440837 <i>ZBTB10</i>, rs7910927 <i>JMJD1C</i>, rs4149056 <i>SLCO1B1</i>, rs8023580 <i>NR2F2</i>, and rs12150660 <i>SHBG</i>-was executed, and the BC-risk impact of these loci was analyzed by logistic regression separately in each group o","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-05-20T03:16:29.017Z","creation":"2026-05-20T03:07:46.945Z"},"accession":"S-EPMC11048332","cross_references":{"pubmed":["38672173"],"doi":["10.3390/biomedicines12040818"]}}