biostudies-literatureUnknown12(4)Ponomarenko IThe purpose of this work was to find a link between the breast cancer (BC)-risk effects of sex hormone-binding globulin (SHBG)-associated polymorphisms and obesity. The study was conducted on a sample of 1498 women (358 BC; 1140 controls) who, depending on the presence/absence of obesity, were divided into two groups: obese (119 BC; 253 controls) and non-obese (239 BC; 887 controls). Genotyping of nine SHBG-associated single nucleotide polymorphisms (SNP)-rs17496332 <i>PRMT6</i>, rs780093 <i>GCKR</i>, rs10454142 <i>PPP1R21</i>, rs3779195 <i>BAIAP2L1</i>, rs440837 <i>ZBTB10</i>, rs7910927 <i>JMJD1C</i>, rs4149056 <i>SLCO1B1</i>, rs8023580 <i>NR2F2</i>, and rs12150660 <i>SHBG</i>-was executed, and the BC-risk impact of these loci was analyzed by logistic regression separately in each group oBiomedicines818https://www.ebi.ac.uk/biostudies/studies/S-EPMC11048332biostudies-literatureObesity-Dependent Association of the rs10454142 <i>PPP1R21</i> with Breast Cancer.PMC11048332Pasenov KChurnosov VChurnosova MPonomarenko MSorokina IAristova IChurnosov MReshetnikova YReshetnikov EPonomarenko IfalseObesity-Dependent Association of the rs10454142 <i>PPP1R21</i> with Breast Cancer.The purpose of this work was to find a link between the breast cancer (BC)-risk effects of sex hormone-binding globulin (SHBG)-associated polymorphisms and obesity. The study was conducted on a sample of 1498 women (358 BC; 1140 controls) who, depending on the presence/absence of obesity, were divided into two groups: obese (119 BC; 253 controls) and non-obese (239 BC; 887 controls). Genotyping of nine SHBG-associated single nucleotide polymorphisms (SNP)-rs17496332 <i>PRMT6</i>, rs780093 <i>GCKR</i>, rs10454142 <i>PPP1R21</i>, rs3779195 <i>BAIAP2L1</i>, rs440837 <i>ZBTB10</i>, rs7910927 <i>JMJD1C</i>, rs4149056 <i>SLCO1B1</i>, rs8023580 <i>NR2F2</i>, and rs12150660 <i>SHBG</i>-was executed, and the BC-risk impact of these loci was analyzed by logistic regression separately in each group o2024-01-01T00:00:00Z2024 Apr2026-05-20T03:16:29.017Z2026-05-20T03:07:46.945ZS-EPMC110483323867217310.3390/biomedicines12040818