{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(4)"],"submitter":["Neri L"],"pubmed_abstract":["ADHD is a neurodevelopmental disorder that children and adults can develop. A complex interplay of genetic and environmental factors may underlie interindividual variability in ADHD and potentially related aggressive behavior. Using high-resolution molecular biology techniques, we investigated the impact of some MAOA and SLC6A4 variations on ADHD and aggressive behavior in a group of 80 Italian children with ADHD and in 80 healthy controls. We found that homozygous genotypes of MAOA rs6323 and rs1137070 were associated with an increased risk of ADHD (<i>p</i> = 0.02 and <i>p</i> = 0.03, respectively), whereas the heterozygous genotypes (GT of rs6323 and CT of rs1137030) (<i>p</i> = 0.0002 and <i>p</i> = 0.0006) were strongly linked to a lower risk of developing this disorder. In patients w"],"journal":["Diseases (Basel, Switzerland)"],"pagination":["70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11049508"],"repository":["biostudies-literature"],"pubmed_title":["Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement."],"pmcid":["PMC11049508"],"pubmed_authors":["Neri L","Del Beato T","Colanardi A","Sebastiani P","Aureli A","Marziani B","Legge MP"],"additional_accession":[]},"is_claimable":false,"name":"Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement.","description":"ADHD is a neurodevelopmental disorder that children and adults can develop. A complex interplay of genetic and environmental factors may underlie interindividual variability in ADHD and potentially related aggressive behavior. Using high-resolution molecular biology techniques, we investigated the impact of some MAOA and SLC6A4 variations on ADHD and aggressive behavior in a group of 80 Italian children with ADHD and in 80 healthy controls. We found that homozygous genotypes of MAOA rs6323 and rs1137070 were associated with an increased risk of ADHD (<i>p</i> = 0.02 and <i>p</i> = 0.03, respectively), whereas the heterozygous genotypes (GT of rs6323 and CT of rs1137030) (<i>p</i> = 0.0002 and <i>p</i> = 0.0006) were strongly linked to a lower risk of developing this disorder. In patients w","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-04-08T15:21:41.04Z","creation":"2026-04-08T04:27:28.35Z"},"accession":"S-EPMC11049508","cross_references":{"pubmed":["38667528"],"doi":["10.3390/diseases12040070"]}}