biostudies-literatureUnknown12(4)Neri LADHD is a neurodevelopmental disorder that children and adults can develop. A complex interplay of genetic and environmental factors may underlie interindividual variability in ADHD and potentially related aggressive behavior. Using high-resolution molecular biology techniques, we investigated the impact of some MAOA and SLC6A4 variations on ADHD and aggressive behavior in a group of 80 Italian children with ADHD and in 80 healthy controls. We found that homozygous genotypes of MAOA rs6323 and rs1137070 were associated with an increased risk of ADHD (<i>p</i> = 0.02 and <i>p</i> = 0.03, respectively), whereas the heterozygous genotypes (GT of rs6323 and CT of rs1137030) (<i>p</i> = 0.0002 and <i>p</i> = 0.0006) were strongly linked to a lower risk of developing this disorder. In patients wDiseases (Basel, Switzerland)70https://www.ebi.ac.uk/biostudies/studies/S-EPMC11049508biostudies-literatureAggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement.PMC11049508Neri LDel Beato TColanardi ASebastiani PAureli AMarziani BLegge MPfalseAggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement.ADHD is a neurodevelopmental disorder that children and adults can develop. A complex interplay of genetic and environmental factors may underlie interindividual variability in ADHD and potentially related aggressive behavior. Using high-resolution molecular biology techniques, we investigated the impact of some MAOA and SLC6A4 variations on ADHD and aggressive behavior in a group of 80 Italian children with ADHD and in 80 healthy controls. We found that homozygous genotypes of MAOA rs6323 and rs1137070 were associated with an increased risk of ADHD (<i>p</i> = 0.02 and <i>p</i> = 0.03, respectively), whereas the heterozygous genotypes (GT of rs6323 and CT of rs1137030) (<i>p</i> = 0.0002 and <i>p</i> = 0.0006) were strongly linked to a lower risk of developing this disorder. In patients w2024-01-01T00:00:00Z2024 Mar2026-04-08T15:21:41.04Z2026-04-08T04:27:28.35ZS-EPMC110495083866752810.3390/diseases12040070