{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bozsity N"],"funding":["National Research, Development and Innovation Office","National Research, Development, and Innovation Office NKFIH","Ministry of Innovation and Technology of Hungary"],"pagination":["4274"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11050183"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(8)"],"pubmed_abstract":["Directed structural modifications of natural products offer excellent opportunities to develop selectively acting drug candidates. Natural product hybrids represent a particular compound group. The components of hybrids constructed from different molecular entities may result in synergic action with diminished side effects. Steroidal homo- or heterodimers deserve special attention owing to their potentially high anticancer effect. Inspired by our recently described antiproliferative core-modified estrone derivatives, here, we combined them into heterodimers via Cu(I)-catalyzed azide-alkyne cycloaddition reactions. The two <i>trans</i>-16-azido-3-(<i>O</i>-benzyl)-17-hydroxy-13α-estrone derivatives were reacted with 3-<i>O</i>-propargyl-D-secoestrone alcohol or oxime. The antiproliferative "],"journal":["International journal of molecular sciences"],"pubmed_title":["Synthesis of Estrone Heterodimers and Evaluation of Their In Vitro Antiproliferative Activity."],"pmcid":["PMC11050183"],"funding_grant_id":["K 143690","TKP2021-EGA-32","SNN 139323","TKP2021-EGA-17"],"pubmed_authors":["Kele Z","Resch V","Paragi G","Zupko I","Szabo J","Palhazi B","Nagy V","Minorics R","Mernyak E","Bozsity N"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of Estrone Heterodimers and Evaluation of Their In Vitro Antiproliferative Activity.","description":"Directed structural modifications of natural products offer excellent opportunities to develop selectively acting drug candidates. Natural product hybrids represent a particular compound group. The components of hybrids constructed from different molecular entities may result in synergic action with diminished side effects. Steroidal homo- or heterodimers deserve special attention owing to their potentially high anticancer effect. Inspired by our recently described antiproliferative core-modified estrone derivatives, here, we combined them into heterodimers via Cu(I)-catalyzed azide-alkyne cycloaddition reactions. The two <i>trans</i>-16-azido-3-(<i>O</i>-benzyl)-17-hydroxy-13α-estrone derivatives were reacted with 3-<i>O</i>-propargyl-D-secoestrone alcohol or oxime. The antiproliferative ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-05-20T03:15:23.842Z","creation":"2026-05-20T03:07:41.454Z"},"accession":"S-EPMC11050183","cross_references":{"pubmed":["38673860"],"doi":["10.3390/ijms25084274"]}}