{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kondkar AA"],"funding":["King Saud University through the Vice Deanship of Scientific Research Chair and Glaucoma Research Chair in Ophthalmology"],"pagination":["4571"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11050284"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(8)"],"pubmed_abstract":["This study investigated the association between apolipoprotein E (<i>APOE</i>) gene polymorphisms (rs429358 and rs7412) and primary angle-closure glaucoma (PACG) and pseudoexfoliation glaucoma (PXG) in a Saudi cohort. Genotyping of 437 DNA samples (251 controls, 92 PACG, 94 PXG) was conducted using PCR-based Sanger sequencing. The results showed no significant differences in the allele and genotype frequencies of rs429358 and rs7412 between the PACG/PXG cases and controls. Haplotype analysis revealed ε3 as predominant, followed by ε4 and ε2 alleles, with no significant variance in PACG/PXG. However, <i>APOE</i> genotype analysis indicated a significant association between ε2-carriers and PACG (odds ratio = 4.82, 95% CI 1.52-15.26, <i>p</i> = 0.007), whereas no notable association was obser"],"journal":["International journal of molecular sciences"],"pubmed_title":["<i>APOE</i> ε2-Carriers Are Associated with an Increased Risk of Primary Angle-Closure Glaucoma in Patients of Saudi Origin."],"pmcid":["PMC11050284"],"funding_grant_id":["GRC-2024"],"pubmed_authors":["Lobo GP","Osman EA","Alsirhy E","Azad TA","Kondkar AA","Almobarak FA","Sultan T","Radhakrishnan R","Khatlani T","Alshehri AA","Al-Obeidan SA"],"additional_accession":[]},"is_claimable":false,"name":"<i>APOE</i> ε2-Carriers Are Associated with an Increased Risk of Primary Angle-Closure Glaucoma in Patients of Saudi Origin.","description":"This study investigated the association between apolipoprotein E (<i>APOE</i>) gene polymorphisms (rs429358 and rs7412) and primary angle-closure glaucoma (PACG) and pseudoexfoliation glaucoma (PXG) in a Saudi cohort. Genotyping of 437 DNA samples (251 controls, 92 PACG, 94 PXG) was conducted using PCR-based Sanger sequencing. The results showed no significant differences in the allele and genotype frequencies of rs429358 and rs7412 between the PACG/PXG cases and controls. Haplotype analysis revealed ε3 as predominant, followed by ε4 and ε2 alleles, with no significant variance in PACG/PXG. However, <i>APOE</i> genotype analysis indicated a significant association between ε2-carriers and PACG (odds ratio = 4.82, 95% CI 1.52-15.26, <i>p</i> = 0.007), whereas no notable association was obser","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-04-15T03:21:07.484Z","creation":"2026-04-15T03:15:12.888Z"},"accession":"S-EPMC11050284","cross_references":{"pubmed":["38674156"],"doi":["10.3390/ijms25084571"]}}