biostudies-literatureKondkar AAKing Saud University through the Vice Deanship of Scientific Research Chair and Glaucoma Research Chair in Ophthalmology4571https://www.ebi.ac.uk/biostudies/studies/S-EPMC11050284biostudies-literatureUnknown25(8)This study investigated the association between apolipoprotein E (<i>APOE</i>) gene polymorphisms (rs429358 and rs7412) and primary angle-closure glaucoma (PACG) and pseudoexfoliation glaucoma (PXG) in a Saudi cohort. Genotyping of 437 DNA samples (251 controls, 92 PACG, 94 PXG) was conducted using PCR-based Sanger sequencing. The results showed no significant differences in the allele and genotype frequencies of rs429358 and rs7412 between the PACG/PXG cases and controls. Haplotype analysis revealed ε3 as predominant, followed by ε4 and ε2 alleles, with no significant variance in PACG/PXG. However, <i>APOE</i> genotype analysis indicated a significant association between ε2-carriers and PACG (odds ratio = 4.82, 95% CI 1.52-15.26, <i>p</i> = 0.007), whereas no notable association was obserInternational journal of molecular sciences<i>APOE</i> ε2-Carriers Are Associated with an Increased Risk of Primary Angle-Closure Glaucoma in Patients of Saudi Origin.PMC11050284GRC-2024Lobo GPOsman EAAlsirhy EAzad TAKondkar AAAlmobarak FASultan TRadhakrishnan RKhatlani TAlshehri AAAl-Obeidan SAfalse<i>APOE</i> ε2-Carriers Are Associated with an Increased Risk of Primary Angle-Closure Glaucoma in Patients of Saudi Origin.This study investigated the association between apolipoprotein E (<i>APOE</i>) gene polymorphisms (rs429358 and rs7412) and primary angle-closure glaucoma (PACG) and pseudoexfoliation glaucoma (PXG) in a Saudi cohort. Genotyping of 437 DNA samples (251 controls, 92 PACG, 94 PXG) was conducted using PCR-based Sanger sequencing. The results showed no significant differences in the allele and genotype frequencies of rs429358 and rs7412 between the PACG/PXG cases and controls. Haplotype analysis revealed ε3 as predominant, followed by ε4 and ε2 alleles, with no significant variance in PACG/PXG. However, <i>APOE</i> genotype analysis indicated a significant association between ε2-carriers and PACG (odds ratio = 4.82, 95% CI 1.52-15.26, <i>p</i> = 0.007), whereas no notable association was obser2024-01-01T00:00:00Z2024 Apr2026-04-15T03:21:07.484Z2026-04-15T03:15:12.888ZS-EPMC110502843867415610.3390/ijms25084571