{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Machado FJDM"],"funding":["Government of Navarra","Instituto de Salud Carlos III","RICORS-ICTUS","CIBERCV"],"pagination":["4379"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11050408"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(8)"],"pubmed_abstract":["Accurate etiologic diagnosis provides an appropriate secondary prevention and better prognosis in ischemic stroke (IS) patients; still, 45% of IS are cryptogenic, urging us to enhance diagnostic precision. We have studied the transcriptomic content of plasma extracellular vesicles (EVs) (<i>n</i> = 21) to identify potential biomarkers of IS etiologies. The proteins encoded by the selected genes were measured in the sera of IS patients (<i>n</i> = 114) and in hypertensive patients with (<i>n</i> = 78) and without atrial fibrillation (AF) (<i>n</i> = 20). IGFBP-2, the most promising candidate, was studied using immunohistochemistry in the IS thrombi (<i>n</i> = 23) and atrium of AF patients (<i>n</i> = 13). In vitro, the IGFBP-2 blockade was analyzed using thromboelastometry and endothelial "],"journal":["International journal of molecular sciences"],"pubmed_title":["Transcriptomic Analysis of Extracellular Vesicles in the Search for Novel Plasma and Thrombus Biomarkers of Ischemic Stroke Etiologies."],"pmcid":["PMC11050408"],"funding_grant_id":["RD21/0006/0008","PI21/00946","PI22/00436","MINERVA II","PI20/01319","CB16/11/00483"],"pubmed_authors":["Machado FJDM","Gomez SU","Zandio B","Aymerich N","Roncal C","Munoz R","Marta-Enguita J","Herrera M","Marta-Moreno J","Paramo-Fernandez JA","Rodriguez JA","Orbe J","Lopez B","Bermejo R","Gonzalez A"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic Analysis of Extracellular Vesicles in the Search for Novel Plasma and Thrombus Biomarkers of Ischemic Stroke Etiologies.","description":"Accurate etiologic diagnosis provides an appropriate secondary prevention and better prognosis in ischemic stroke (IS) patients; still, 45% of IS are cryptogenic, urging us to enhance diagnostic precision. We have studied the transcriptomic content of plasma extracellular vesicles (EVs) (<i>n</i> = 21) to identify potential biomarkers of IS etiologies. The proteins encoded by the selected genes were measured in the sera of IS patients (<i>n</i> = 114) and in hypertensive patients with (<i>n</i> = 78) and without atrial fibrillation (AF) (<i>n</i> = 20). IGFBP-2, the most promising candidate, was studied using immunohistochemistry in the IS thrombi (<i>n</i> = 23) and atrium of AF patients (<i>n</i> = 13). In vitro, the IGFBP-2 blockade was analyzed using thromboelastometry and endothelial ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-05-20T03:16:02.544Z","creation":"2026-05-20T03:07:44.472Z"},"accession":"S-EPMC11050408","cross_references":{"pubmed":["38673963"],"doi":["10.3390/ijms25084379"]}}