{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qiu D"],"funding":["General Program of the National Natural Science Foundation of China","General Program of National Natural Science Foundation of China","Fundamental Research Funds for the Central Universities","Foundation of 100 Talents Program of Sun Yat-Sen University","National Natural Science Foundation of China"],"pagination":["4469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11050633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(8)"],"pubmed_abstract":["Neuregulin-1 (Nrg1, gene symbol: <i>Nrg1</i>), a ligand of the ErbB receptor family, promotes intestinal epithelial cell proliferation and repair. However, the dynamics and accurate derivation of Nrg1 expression during colitis remain unclear. By analyzing the public single-cell RNA-sequencing datasets and employing a dextran sulfate sodium (DSS)-induced colitis model, we investigated the cell source of <i>Nrg1</i> expression and its potential regulator in the process of epithelial healing. Nrg1 was majorly expressed in stem-like fibroblasts arising early in mouse colon after DSS administration, and Nrg1-Erbb3 signaling was identified as a potential mediator of interaction between stem-like fibroblasts and colonic epithelial cells. During the ongoing colitis phase, a significant infiltratio"],"journal":["International journal of molecular sciences"],"pubmed_title":["Myeloid Cell-Derived IL-1 Signaling Damps Neuregulin-1 from Fibroblasts to Suppress Colitis-Induced Early Repair of the Intestinal Epithelium."],"pmcid":["PMC11050633"],"funding_grant_id":["82370540","Y61231","82070564"],"pubmed_authors":["Qiu D","Tang C","Xu S","Ji K"],"additional_accession":[]},"is_claimable":false,"name":"Myeloid Cell-Derived IL-1 Signaling Damps Neuregulin-1 from Fibroblasts to Suppress Colitis-Induced Early Repair of the Intestinal Epithelium.","description":"Neuregulin-1 (Nrg1, gene symbol: <i>Nrg1</i>), a ligand of the ErbB receptor family, promotes intestinal epithelial cell proliferation and repair. However, the dynamics and accurate derivation of Nrg1 expression during colitis remain unclear. By analyzing the public single-cell RNA-sequencing datasets and employing a dextran sulfate sodium (DSS)-induced colitis model, we investigated the cell source of <i>Nrg1</i> expression and its potential regulator in the process of epithelial healing. Nrg1 was majorly expressed in stem-like fibroblasts arising early in mouse colon after DSS administration, and Nrg1-Erbb3 signaling was identified as a potential mediator of interaction between stem-like fibroblasts and colonic epithelial cells. During the ongoing colitis phase, a significant infiltratio","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-05-29T03:07:12.625Z","creation":"2026-05-29T03:05:43.348Z"},"accession":"S-EPMC11050633","cross_references":{"pubmed":["38674054"],"doi":["10.3390/ijms25084469"]}}