{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qin L"],"funding":["National Natural Science Foundation of China"],"pagination":["271"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11051235"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(4)"],"pubmed_abstract":["Histone post-translational modification is one of the main mechanisms of epigenetic regulation, which plays a crucial role in the control of gene expression and various biological processes. However, whether or not it affects fungal virulence in <i>Sclerotinia sclerotiorum</i> is not clear. In this study, we identified and cloned the histone methyltransferase <i>Defective in methylation 5</i> (<i>Dim5</i>) in <i>S. sclerotiorum</i>, which encodes a protein containing a typical SET domain. <i>SsDim5</i> was found to be dynamically expressed during infection. Knockout experiment demonstrated that deletion of <i>SsDim5</i> reduced the virulence in <i>Ssdim5-1/Ssdim5-2</i> mutant strains, accompanied by a significant decrease in H3K9 trimethylation levels. Transcriptomic analysis further revea"],"journal":["Journal of fungi (Basel, Switzerland)"],"pubmed_title":["Histone Methyltransferase <i>Ss</i>Dim5 Regulates Fungal Virulence through H3K9 Trimethylation in <i>Sclerotinia sclerotiorum</i>."],"pmcid":["PMC11051235"],"funding_grant_id":["grant 31971836","31971836"],"pubmed_authors":["Qin L","Cui K","Xia S","Nong J","Gong X","Zhao Y","Tang X"],"additional_accession":[]},"is_claimable":false,"name":"Histone Methyltransferase <i>Ss</i>Dim5 Regulates Fungal Virulence through H3K9 Trimethylation in <i>Sclerotinia sclerotiorum</i>.","description":"Histone post-translational modification is one of the main mechanisms of epigenetic regulation, which plays a crucial role in the control of gene expression and various biological processes. However, whether or not it affects fungal virulence in <i>Sclerotinia sclerotiorum</i> is not clear. In this study, we identified and cloned the histone methyltransferase <i>Defective in methylation 5</i> (<i>Dim5</i>) in <i>S. sclerotiorum</i>, which encodes a protein containing a typical SET domain. <i>SsDim5</i> was found to be dynamically expressed during infection. Knockout experiment demonstrated that deletion of <i>SsDim5</i> reduced the virulence in <i>Ssdim5-1/Ssdim5-2</i> mutant strains, accompanied by a significant decrease in H3K9 trimethylation levels. Transcriptomic analysis further revea","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-04-13T03:25:20.776Z","creation":"2026-04-13T03:12:50.551Z"},"accession":"S-EPMC11051235","cross_references":{"pubmed":["38667942"],"doi":["10.3390/jof10040271"]}}