{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45(5)"],"submitter":["Li LB"],"pubmed_abstract":["Paclitaxel resistance is associated with a poor prognosis in non-small cell lung cancer (NSCLC) patients, and currently, there is no promising drug for paclitaxel resistance. In this study, we investigated the molecular mechanisms underlying the chemoresistance in human NSCLC-derived cell lines. We constructed paclitaxel-resistant NSCLC cell lines (A549/PR and H460/PR) by long-term exposure to paclitaxel. We found that triptolide, a diterpenoid epoxide isolated from the Chinese medicinal herb Tripterygium wilfordii Hook F, effectively enhanced the sensitivity of paclitaxel-resistant cells to paclitaxel by reducing ABCB1 expression in vivo and in vitro. Through high-throughput sequencing, we identified the SHH-initiated Hedgehog signaling pathway playing an important role in this process. W"],"journal":["Acta pharmacologica Sinica"],"pagination":["1060-1076"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11053095"],"repository":["biostudies-literature"],"pubmed_title":["Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer."],"pmcid":["PMC11053095"],"pubmed_authors":["Wen H","Zhao XG","Liu L","Yang LX","Li AH","Li LB","Liu FR","Li PC","Sun H","Tian ZX","Xue X","Zhu YL"],"additional_accession":[]},"is_claimable":false,"name":"Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer.","description":"Paclitaxel resistance is associated with a poor prognosis in non-small cell lung cancer (NSCLC) patients, and currently, there is no promising drug for paclitaxel resistance. In this study, we investigated the molecular mechanisms underlying the chemoresistance in human NSCLC-derived cell lines. We constructed paclitaxel-resistant NSCLC cell lines (A549/PR and H460/PR) by long-term exposure to paclitaxel. We found that triptolide, a diterpenoid epoxide isolated from the Chinese medicinal herb Tripterygium wilfordii Hook F, effectively enhanced the sensitivity of paclitaxel-resistant cells to paclitaxel by reducing ABCB1 expression in vivo and in vitro. Through high-throughput sequencing, we identified the SHH-initiated Hedgehog signaling pathway playing an important role in this process. W","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-07-15T10:38:02.39Z","creation":"2026-07-03T03:14:46.059Z"},"accession":"S-EPMC11053095","cross_references":{"pubmed":["38228910"],"doi":["10.1038/s41401-023-01219-y"]}}