biostudies-literatureZreibe KNICHD NIH HHSNational Institute of Child Health and Human Development77-83https://www.ebi.ac.uk/biostudies/studies/S-EPMC11056288biostudies-literatureUnknown110<h4>Background</h4>Individuals with PPP2R5D-related neurodevelopmental disorder have an atypical gait pattern characterized by ataxia and incoordination. Structured, quantitative assessments are needed to further understand the impact of these impairments on function.<h4>Research question</h4>How do gait parameters and ambulatory function of individuals with PPP2R5D-related neurodevelopmental disorder compare to age and sex matched healthy norms?<h4>Methods</h4>Twenty-six individuals with PPP2R5D pathogenic genetic variants participated in this observational, single visit study. Participants completed at least one of the following gait assessments: quantitative gait analysis at three different speeds (preferred pace walking (PPW), fast paced walking (FPW) and running, six-minute walk test Gait & postureCharacterizing ambulatory function in children with PPP2R5D-related neurodevelopmental disorder.PMC11056288P50 HD109879P50 HD105351Chung WKUher DHarris MZreibe KMontes JKanner CHCalamia SBeard GPatterson MDoerger JfalseCharacterizing ambulatory function in children with PPP2R5D-related neurodevelopmental disorder.<h4>Background</h4>Individuals with PPP2R5D-related neurodevelopmental disorder have an atypical gait pattern characterized by ataxia and incoordination. Structured, quantitative assessments are needed to further understand the impact of these impairments on function.<h4>Research question</h4>How do gait parameters and ambulatory function of individuals with PPP2R5D-related neurodevelopmental disorder compare to age and sex matched healthy norms?<h4>Methods</h4>Twenty-six individuals with PPP2R5D pathogenic genetic variants participated in this observational, single visit study. Participants completed at least one of the following gait assessments: quantitative gait analysis at three different speeds (preferred pace walking (PPW), fast paced walking (FPW) and running, six-minute walk test 2024-01-01T00:00:00Z2024 May2026-06-02T20:44:08.19Z2026-04-20T03:10:35.694ZS-EPMC110562883854767610.1016/j.gaitpost.2024.03.012