biostudies-literatureADEQUATE Paediatric Trial GroupInnovative Medicines InitiativeWellcome Truste076338https://www.ebi.ac.uk/biostudies/studies/S-EPMC11057286biostudies-literatureUnknown14(4)<h4>Introduction</h4>Syndromic panel assays, that is, using one test to simultaneously target multiple pathogens with overlapping signs and symptoms, have been integrated into routine paediatric care over the past decade, mainly for more severely ill and hospitalised patients. Their wider availability and short turnaround times open the possibility to apply them to non-hospitalised patients as well. In this context, it is important to trial how clinicians make use of pathogen detection data and if their early availability influences management decisions, particularly antibiotic use and hospitalisation.<h4>Methods and analysis</h4>Advanced Diagnostics for Enhanced QUality of Antibiotic prescription in respiratory Tract infections in Emergency rooms is an individually randomised, controlled,BMJ openRandomised multicentre effectiveness trial of rapid syndromic testing by panel assay in children presenting to European emergency departments with acute respiratory infections-trial protocol for the ADEQUATE Paediatric trial.PMC11057286820755van Asselt TLampada CHill LFMalhotra-Kumar SVanoni FGardiner EHultin CCharisi KMarten AHeijerman HBehret FMesa SFruh EHernandez ID'Ambrosio FSeoane AWerner CBouwman WCalderon RNyirenda Nyang'wa Mde Pooter DFtergioti AChorafa EGualco GBonten MHemeson Avan Dorst PRoilides ESeveri Conti ARojas PRojo PTessonneau MLeus Fvan Esschoten MVecchia GMichailidou EBerger RRodriguez Ruiz JPWalter TPantzartzi KStiegler AKBrock LCleuziat PPeter SPfeiffer LZarras KDawoud DAtkinson AHommel BRenk Hvan Werkhoven HKarypiadou AVandepitte SVitale EYau YClements MSimitsopoulou MSavvidou PTimbermont LBielicki JAPrat Aymerich COviedo LAllantaz FLyttle MJunk CCabello LRoss Avan der Pol SHawksworth CGijon MBaron LImort DBelschner MTissier JLGonzales MKitsou MGoossens HAntonanzas FMachin FIosifidis ECapozzi LADEQUATE Paediatric Trial GroupPostma MJSeyfried MKohns Vasconcelos MRobinson EKiesel KSchmauder KTsiatsiou OfalseRandomised multicentre effectiveness trial of rapid syndromic testing by panel assay in children presenting to European emergency departments with acute respiratory infections-trial protocol for the ADEQUATE Paediatric trial.<h4>Introduction</h4>Syndromic panel assays, that is, using one test to simultaneously target multiple pathogens with overlapping signs and symptoms, have been integrated into routine paediatric care over the past decade, mainly for more severely ill and hospitalised patients. Their wider availability and short turnaround times open the possibility to apply them to non-hospitalised patients as well. In this context, it is important to trial how clinicians make use of pathogen detection data and if their early availability influences management decisions, particularly antibiotic use and hospitalisation.<h4>Methods and analysis</h4>Advanced Diagnostics for Enhanced QUality of Antibiotic prescription in respiratory Tract infections in Emergency rooms is an individually randomised, controlled,2024-01-01T00:00:00Z2024 Apr2026-05-29T12:36:19.879Z2026-04-08T04:50:48.509ZS-EPMC110572863867062210.1136/bmjopen-2023-076338