{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Ghaffar SA"],"pubmed_abstract":["<i>Haemophilus parainfluenzae</i> is a Gram-negative opportunist pathogen within the mucus of the nose and mouth without significant symptoms and has an ability to cause various infections ranging from ear, eye, and sinus to pneumonia. A concerning development is the increasing resistance of <i>H. parainfluenzae</i> to beta-lactam antibiotics, with the potential to cause dental infections or abscesses. The principal objective of this investigation is to utilize bioinformatics and immuno-informatic methodologies in the development of a candidate multi-epitope Vaccine. The investigation focuses on identifying potential epitopes for both B cells (B lymphocytes) and T cells (helper T lymphocytes and cytotoxic T lymphocytes) based on high non-toxic and non-allergenic characteristics. The select"],"journal":["Frontiers in immunology"],"pagination":["1380732"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11058264"],"repository":["biostudies-literature"],"pubmed_title":["Designing of a multi-epitopes based vaccine against <i>Haemophilius parainfluenzae</i> and its validation through integrated computational approaches."],"pmcid":["PMC11058264"],"pubmed_authors":["Tahir H","Faisal M","Muhammad S","Albekairi NA","Albekairi TH","Naqqash T","Shahid M","Ghaffar SA","Alshammari A","Manzoor I"],"additional_accession":[]},"is_claimable":false,"name":"Designing of a multi-epitopes based vaccine against <i>Haemophilius parainfluenzae</i> and its validation through integrated computational approaches.","description":"<i>Haemophilus parainfluenzae</i> is a Gram-negative opportunist pathogen within the mucus of the nose and mouth without significant symptoms and has an ability to cause various infections ranging from ear, eye, and sinus to pneumonia. A concerning development is the increasing resistance of <i>H. parainfluenzae</i> to beta-lactam antibiotics, with the potential to cause dental infections or abscesses. The principal objective of this investigation is to utilize bioinformatics and immuno-informatic methodologies in the development of a candidate multi-epitope Vaccine. The investigation focuses on identifying potential epitopes for both B cells (B lymphocytes) and T cells (helper T lymphocytes and cytotoxic T lymphocytes) based on high non-toxic and non-allergenic characteristics. The select","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-04-08T18:55:48.666Z","creation":"2026-04-08T11:13:10.015Z"},"accession":"S-EPMC11058264","cross_references":{"pubmed":["38690283"],"doi":["10.3389/fimmu.2024.1380732"]}}