biostudies-literatureUnknown15Ghaffar SA<i>Haemophilus parainfluenzae</i> is a Gram-negative opportunist pathogen within the mucus of the nose and mouth without significant symptoms and has an ability to cause various infections ranging from ear, eye, and sinus to pneumonia. A concerning development is the increasing resistance of <i>H. parainfluenzae</i> to beta-lactam antibiotics, with the potential to cause dental infections or abscesses. The principal objective of this investigation is to utilize bioinformatics and immuno-informatic methodologies in the development of a candidate multi-epitope Vaccine. The investigation focuses on identifying potential epitopes for both B cells (B lymphocytes) and T cells (helper T lymphocytes and cytotoxic T lymphocytes) based on high non-toxic and non-allergenic characteristics. The selectFrontiers in immunology1380732https://www.ebi.ac.uk/biostudies/studies/S-EPMC11058264biostudies-literatureDesigning of a multi-epitopes based vaccine against <i>Haemophilius parainfluenzae</i> and its validation through integrated computational approaches.PMC11058264Tahir HFaisal MMuhammad SAlbekairi NAAlbekairi THNaqqash TShahid MGhaffar SAAlshammari AManzoor IfalseDesigning of a multi-epitopes based vaccine against <i>Haemophilius parainfluenzae</i> and its validation through integrated computational approaches.<i>Haemophilus parainfluenzae</i> is a Gram-negative opportunist pathogen within the mucus of the nose and mouth without significant symptoms and has an ability to cause various infections ranging from ear, eye, and sinus to pneumonia. A concerning development is the increasing resistance of <i>H. parainfluenzae</i> to beta-lactam antibiotics, with the potential to cause dental infections or abscesses. The principal objective of this investigation is to utilize bioinformatics and immuno-informatic methodologies in the development of a candidate multi-epitope Vaccine. The investigation focuses on identifying potential epitopes for both B cells (B lymphocytes) and T cells (helper T lymphocytes and cytotoxic T lymphocytes) based on high non-toxic and non-allergenic characteristics. The select2024-01-01T00:00:00Z20242026-04-08T18:55:48.666Z2026-04-08T11:13:10.015ZS-EPMC110582643869028310.3389/fimmu.2024.1380732