{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["103"],"submitter":["Messina NL"],"funding":["Swiss National Science Foundation","NHMRC","Bill and Melinda Gates Foundation","The Royal Children&apos;s Hospital Foundation"],"pubmed_abstract":["<h4>Background</h4>The COVID-19 pandemic led to the rapid development and deployment of several highly effective vaccines against SARS-CoV-2. Recent studies suggest that these vaccines may also have off-target effects on the immune system. We sought to determine and compare the off-target effects of the adenovirus vector ChAdOx1-S (Oxford-AstraZeneca) and modified mRNA BNT162b2 (Pfizer-BioNTech) vaccines on immune responses to unrelated pathogens.<h4>Methods</h4>Prospective sub-study within the BRACE trial. Blood samples were collected from 284 healthcare workers before and 28 days after ChAdOx1-S or BNT162b2 vaccination. SARS-CoV-2-specific antibodies were measured using ELISA, and whole blood cytokine responses to specific (SARS-CoV-2) and unrelated pathogen stimulation were measured by "],"journal":["EBioMedicine"],"pagination":["105100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11058726"],"repository":["biostudies-literature"],"pubmed_title":["Specific and off-target immune responses following COVID-19 vaccination with ChAdOx1-S and BNT162b2 vaccines-an exploratory sub-study of the BRACE trial."],"pmcid":["PMC11058726"],"pubmed_authors":["Young A","Pelayo L","Shave M","Dawe P","Gardiner K","Douglas M","Al-Hindawi Y","Rodrigues L","van der Waal M","Gardiner E","Plit M","Glenn P","Gladanac B","Herrmann S","Manning L","Walker M","Meek B","Vidmar S","Mojeed J","Correa E Castro G","Romme J","Barros D","Oever JT","Serna A","Wee-Hee A","Fernandes IR","Baulman T","Rodrigues B","Jimenez VP","Bergant N","Santos E","Bennett-Wood V","Sondag T","Santos D","Kaynes A","Meehan A","Keeble T","Fletcher E","Ramirez de Arellano E","Bartlett A","Hassing RJ","Brizuela R","Oliveira MG","Valero O","Moreno E","Freitas T","Santos T","Roescher N","Lieschke K","Miller S","Cristine de Moraes Dos Santos V","Lalich D","Lynn DJ","Rhodes S","Paiva Romano JV","Wedderburn J","Hinojosa D","Dang T","Jenkins N","Dolores Del Toro Lopez M","Verheij H","Oppedisano F","da Costa Silva R","Garcia Meireless Junior PL","Rosell A","Placido Pereira RM","Mead L","Rijen MMLMV","Huijbens D","Cheah J","Silva De Freitas ML","Janssen A","Quinn L","Marins A","Eastwood O","Barry S","Huijs L","Wadia U","Dominguez J","Lima A","Sterling K","Silva DDS","Symons L","Onysk J","Arroyo SF","Edler P","Marti CB","Richmond P","Amenyogbe N","Molina B","Waring J","Abreu C","Fowler S","Messina NL","Bahaduri T","Molina G","Dunn R","Carlin J","Salmon A","Porcuna TP","Mezzetti I","Carter C","Sperotto MG","Garcia PB","Brophy C","Winder R","Hilton S","La N","Eden G","Spotswood J","Filius M","Catterick H","Perrett KP","Campos Angelo JT","Gamage D","Almeida da Silveira S","Sharma K","Nascimento E","Rodriguez-Bano J","Gifford A","Spry L","Junior J","Navarrete N","Beardsley J","Lemmens T","De Floy AP","Kluytmans J","Jarvis L","Dunn A","Besten HO","Ma N","Stevens L","Erkaya I","Stevens N","Elborough H","O'Bryan J","Ghieh R","Perez C","Fouracre L","Jorge L","Perez G","Heath C","Arnold A","Webber-Rookes D","Ooi I","McMullan B","Krieg M","Latorre I","Ong B","Leopoldina Meireles BT","Hilton Z","Latkovic E","Bonnici R","Prado C","Martin C","Vasconcelos H","Anderson J","Maria da Silva Passos de Carvalho A","Stevens A","Dao A","Vasconcelos A","Souza de Almeida Dos Reis Pereira AA","Paes R","Sampaio V","Tadokoro MM","Ong J","Anthony C","Arnaiz de Las Revillas Almajano F","Orsini F","Shen L","Chengodu T","Pandine GDS","Puga M","Gordon V","Street R","Castro R","Costa E","Liang I","Stewart C","Ben-Othman R","Guo C","Ribeiro Dos Santos C","Younes A","Bateman F","Toogood N","Hutton H","Parkin K","Razmovska M","Bimboese P","Amo EC","Eggenhuizen E","Statton S","Mazurega K","Rajaram G","Byrne J","Ciaverella M","Byrne B","Sidaway-Lee K","Byrne A","Bustos N","Ewe K","Steve L","Scheppokat A","Minhaj A","Doblas PC","van Opdorp M","Stooper L","Uren C","Conceicao de Souza AP","Alamrousi A","McElroy R","Gell G","Barney S","Kent J","Ren J","Vega N","Santos KM","McCafferty C","Dawson D","Casas I","Sousa A","Mitchell K","Montgomery L","Andrit MG","Knight B","Mitchell M","Trindade A","Curtis N","Reynolds S","Curtis M","Sanchez B","Brans E","Finucane C","Richmond H","Stevens NE","Clarke A","Wood N","Dijkstra H","Bowes K","Colaco C","Godinho V","Hammond C","Davidson A","Freitas da Rosa Soares B","Esteve M","Reddiex S","Lynn M","Singh R","Guerrero RC","Mathers M","Lynn D","Germano S","Troeman D","Nguyen NK","Lockhart G","Rezazadeh S","Lacoma A","Silva AB","Lopes Alves da Paixao CM","Villanueva P","van Sluis N","Sawka A","Rak A","Jamieson T","Richards C","Hannan M","Gouy C","Teo JW","Warris A","Kakkos A","Velagapudi S","Edmund H","Grubor-Bauk B","BRACE trial","Tristan E","Bitencourt de Andrade C","Fernandes da Silva E","Barrera L","Gomes-Silva A","Lagunday R","Queiroz E","Santos GD","Netea M","Dutra Escobar RC","Bannister S","Stone S","Lopes Dos Santos K","Blake S","Simao M","Marshall H","Ali R","Preijers L","Olivo de Mendonca LM","Maia B","Castellano AD","Olivier N","Collopy SS","Crawford N","Calbo E","Boersma W","Osman H","Desylva M","Williams F","Gama L","James J","Val F","Warszawski de Oliveira KR","Hartnell L","Santos AG","Gibbons M","De La Cruz K","Chern TY","Bonten M","Luiz da Rocha J","Tripp H","Hall L","Watkins D","Subbarao K","Hall R","Andrade PH","Fahey K","Gibson C","Silva J","Cuadra MG","Rico CG","Otsuka A","Croda J","Gwee A","Arrowsmith B","Prat-Aymerich C","Lahdo S","Matos LS","Pon R","Vlahos A","Ratcliffe S","Skut P","England M","Williams P","Silva E","Post J","Hamilton K","Brakke KM","Corbett M","Nicol K","Heine RT","Cain N","Pretti Dalcolmo MM","Palasanthiran P","Clement Espindola MA","Farinas Alvarez MC","Kollmann T","Henare N","Da-Cruz AM","Pereira G","Koopmans MAH","van Mook L","Sastry A","Munns C","Motta FDC","Wall K","Kloeg P","Nicholson S","Pereira H","Venton T","Milojevic E","Stadhouders K","Cobbledick A","Pano TR","de Jesus Costa M","Neves J","Alcoforado da Silva Dos Santos A","Bealing M","Pranger E","McDonald E","Agius S","McDonald F","Noonan F","Riele MT","Greven F","Firth S","Hill E","Capella AG","Perrett K","Overton K","Benson S","Cushnahan J","Evans S","Rudraraju R","Flynn L","Lencina JDS","Rol A","de Oliveira A","Flynn C","Brasil L","Vieira de Oliveira M","Czajko A","Dunnill J","Medeiros T","Refosco Barbosa AA","Jones J","Jones K","Barnes A","Pitkin S","Pereira da Silva PC","Prudencio Soares AC","Lim R","van den Bijllaardt W","Camesella B","Toh R","Silva Menezes Arruda BM","Wallace R","Moraes M","Peeters R","Harbech H","Boon A","O'Callaghan S","Markow A","Morawakage T","Hernandez AP","Oliveira T","Sooriyarachchi E","Paternotte N","Goncalvez de Araujo Arcanjo G","Bell J","Mendonca Teixeira de Siqueira MA","Vieira Batista FZ","Molenaar-Groot K","Moore J","Krastev A","Watts E","Rocha da Silva PV","Moorlag S","Souza da Rosa TH","Moore C","O'Donnell M","O'Donnell L","Burns A","Lim K","Moss J","Legge D","Lacerda M","Oliveira I","Jardim B","Vieira da Silva P","Joyce R","de Cassia Batista R","McPhate N","Studham J","Pittet LF","Wesselingh S","Mazarakis N","Lucas M","Silva Muranaka LB","Chan J","Burrell E","Palomares ET","McMillan M","Newman G","Jardim T","Sartim A","Martin Gutierrez AB","Davies P","Wolters B","Norton W","Pereira Diogo RC","Rios Villegas MJ","Vidal S","Clark S","Carretero JM","Goncalves MP","Septer-Bijleveld E","Machingaifa F","Thomson H","McAlister S","Maia IR","Lee K","Abruzzo V","Ayala WE","Rayner V","Barriocanal A","Zhou C","Goodall C","Ortika B","Ramos CV","de Morais Batista F","Fernandez M","Moyle W","Ferreira K","Calderon IP","Ramos P","de Souza D","Leopoldina Dos Santos DS","Gisolf J","Buchanan S","Elia S","Moreira DQ","Elkington O","Taks E","Pell C","Hollams E","Lee W","Barbosa FB","Leurink T","Azzopardi K","Jennings E","Odoi S","Huang H","Wearing-Smith M","Melo R","Gerhardt de Oliveira Ferreira A","Campos DG","Manton S","Garces AC","Xie I","Kandasamy R","Fortunato AL","Barriocanal AM","Goikoetxea J","Wang X","Karunanayake A","Poderos TG","Tan N","Pittet L","Cavalcanti Goncalves LG","Goodchild L","Botten R","Soares C","Griffith L","Truelove A","O'Connell A","Doran C","Stiglmayer L","McAnew A","Eiffler N","Addlem L","Blauwendraat K","Bourke A","Sudbury E","Power C","Croda MG","Hua J","Rogers S","Sherry B","Whale B","Dias de Oliveira R","Schultz N","Ngien B","Ramos Vieira HM","Figueiredo P","Joshi S","Korman T","Messina N","Bucholc J","Ellinghaus A","Nguyen T","Figueiredo LR","van Leusen J","Furtado AC","Compagnone R","Almeida KM","Teodoro de Lima G","Martins da Costa Carvalho E","Nguyen J","Alves da Cruz L","Harding A","Alves Dos Santos Gomes D","Campbell J","Cranston T","Perlen S","Macalister S","Tsuha D","Kirkwood J","Dias M","Sacca D","Dias J"],"additional_accession":[]},"is_claimable":false,"name":"Specific and off-target immune responses following COVID-19 vaccination with ChAdOx1-S and BNT162b2 vaccines-an exploratory sub-study of the BRACE trial.","description":"<h4>Background</h4>The COVID-19 pandemic led to the rapid development and deployment of several highly effective vaccines against SARS-CoV-2. Recent studies suggest that these vaccines may also have off-target effects on the immune system. We sought to determine and compare the off-target effects of the adenovirus vector ChAdOx1-S (Oxford-AstraZeneca) and modified mRNA BNT162b2 (Pfizer-BioNTech) vaccines on immune responses to unrelated pathogens.<h4>Methods</h4>Prospective sub-study within the BRACE trial. Blood samples were collected from 284 healthcare workers before and 28 days after ChAdOx1-S or BNT162b2 vaccination. SARS-CoV-2-specific antibodies were measured using ELISA, and whole blood cytokine responses to specific (SARS-CoV-2) and unrelated pathogen stimulation were measured by ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T08:55:39.712Z","creation":"2026-04-16T03:12:56.178Z"},"accession":"S-EPMC11058726","cross_references":{"pubmed":["38663355"],"doi":["10.1016/j.ebiom.2024.105100"]}}