{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["84"],"submitter":["Desmet SJ"],"funding":["UGent","FWO"],"pubmed_abstract":["<h4>Objective</h4>The peroxisome proliferator-activated receptor α (PPARα) is a transcription factor driving target genes involved in fatty acid β-oxidation. To what extent various PPARα interacting proteins may assist its function as a transcription factor is incompletely understood. An ORFeome-wide unbiased mammalian protein-protein interaction trap (MAPPIT) using PPARα as bait revealed a PPARα-ligand-dependent interaction with the orphan nuclear receptor estrogen-related receptor α (ERRα). The goal of this study was to characterize the nature of the interaction in depth and to explore whether it was of physiological relevance.<h4>Methods</h4>We used orthogonal protein-protein interaction assays and pharmacological inhibitors of ERRα in various systems to confirm a functional interaction"],"journal":["Molecular metabolism"],"pagination":["101938"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11059514"],"repository":["biostudies-literature"],"pubmed_title":["Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression."],"pmcid":["PMC11059514"],"pubmed_authors":["Brunsveld L","Libert C","Peelman F","Ratman D","Timmermans S","De Bosscher K","De Cauwer L","Li Y","Fijalkowska D","Staels B","Desmet SJ","Vandenboorn EMF","Thommis J","Van Hamme E","Tavernier J","Vanderhaeghen T","Clarisse D"],"additional_accession":[]},"is_claimable":false,"name":"Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression.","description":"<h4>Objective</h4>The peroxisome proliferator-activated receptor α (PPARα) is a transcription factor driving target genes involved in fatty acid β-oxidation. To what extent various PPARα interacting proteins may assist its function as a transcription factor is incompletely understood. An ORFeome-wide unbiased mammalian protein-protein interaction trap (MAPPIT) using PPARα as bait revealed a PPARα-ligand-dependent interaction with the orphan nuclear receptor estrogen-related receptor α (ERRα). The goal of this study was to characterize the nature of the interaction in depth and to explore whether it was of physiological relevance.<h4>Methods</h4>We used orthogonal protein-protein interaction assays and pharmacological inhibitors of ERRα in various systems to confirm a functional interaction","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-02T22:47:18.838Z","creation":"2026-04-21T03:13:29.595Z"},"accession":"S-EPMC11059514","cross_references":{"pubmed":["38631478"],"doi":["10.1016/j.molmet.2024.101938"]}}