biostudies-literatureBang SNIDCR NIH HHSNIDA NIH HHSNINDS NIH HHSe173537https://www.ebi.ac.uk/biostudies/studies/S-EPMC11060744biostudies-literatureUnknown134(9)G protein-coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown functions. Here, we report that Gpr37l1/GRP37L1 ranks among the most highly expressed GPCR transcripts in mouse and human dorsal root ganglia (DRGs) and is selectively expressed in satellite glial cells (SGCs). Peripheral neuropathy induced by streptozotoxin (STZ) and paclitaxel (PTX) led to reduced GPR37L1 expression on the plasma membrane in mouse and human DRGs. Transgenic mice with Gpr37l1 deficiency exhibited impaired resolution of neuropathic pain symptoms following PTX- and STZ-induced pain, whereas overexpression of Gpr37l1 in mouse DRGs reversed pain. GPR37L1 is coexpressed with potassium channels, including KCNJ10 (Kir4.1) in mouse SGCs and both KCNJ3 (Kir3.1) and KCNJ10 in human SGCs. GPR37L1 rThe Journal of clinical investigationSatellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis.PMC11060744RF1 NS131812U54 DA049110R01 NS113243R01 DE017794R03 DE032394Bang SBerta TJi RRMcGinnis AJahangiri Esfahani SHe QTonello RXu JZhang QLi YFernandes de Araujo LOAo XJiang CLuo XWang ZParisien MChandra SDiatchenko LfalseSatellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis.G protein-coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown functions. Here, we report that Gpr37l1/GRP37L1 ranks among the most highly expressed GPCR transcripts in mouse and human dorsal root ganglia (DRGs) and is selectively expressed in satellite glial cells (SGCs). Peripheral neuropathy induced by streptozotoxin (STZ) and paclitaxel (PTX) led to reduced GPR37L1 expression on the plasma membrane in mouse and human DRGs. Transgenic mice with Gpr37l1 deficiency exhibited impaired resolution of neuropathic pain symptoms following PTX- and STZ-induced pain, whereas overexpression of Gpr37l1 in mouse DRGs reversed pain. GPR37L1 is coexpressed with potassium channels, including KCNJ10 (Kir4.1) in mouse SGCs and both KCNJ3 (Kir3.1) and KCNJ10 in human SGCs. GPR37L1 r2024-01-01T00:00:00Z2024 Mar2026-06-01T09:23:21.145Z2026-04-08T11:11:01.386ZS-EPMC110607443853036410.1172/JCI173537