{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dadgar N"],"funding":["NHLBI NIH HHS","NCI NIH HHS","A Glimmer of Hope"],"pagination":["402"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11061933"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work identifying high concentrations of the cytokine interleukin-6 (IL-6) and its soluble receptor (sIL-6-Rα) in the peritoneal cavity of patients with PC has highlighted this pathway as an emerging potential therapeutic target. This review article provides a comprehensive overview of the current understanding of the potential role of IL-6 in the development and progression of PC. We discuss mechansims by which the IL-6 pathway may contribute to peritoneal tumor dissemination, mesothelial adhesion and invasion, stromal invasion and proliferation, and immune response modulation. Finally, we review the prospects for targeting the IL-6 pathway in the trea"],"journal":["Journal of translational medicine"],"pubmed_title":["Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis."],"pmcid":["PMC11061933"],"funding_grant_id":["T32 HL160526","R37 CA232209","R01 CA114246","A Glimmer of Hope"],"pubmed_authors":["Wagner PL","Donnenberg V","Park H","Sherry C","Zaidi AH","Fan Y","Dadgar N","Xiao K","Bartlett D","Lewis C","Zimmerman J","Donnenberg A"],"additional_accession":[]},"is_claimable":false,"name":"Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis.","description":"Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work identifying high concentrations of the cytokine interleukin-6 (IL-6) and its soluble receptor (sIL-6-Rα) in the peritoneal cavity of patients with PC has highlighted this pathway as an emerging potential therapeutic target. This review article provides a comprehensive overview of the current understanding of the potential role of IL-6 in the development and progression of PC. We discuss mechansims by which the IL-6 pathway may contribute to peritoneal tumor dissemination, mesothelial adhesion and invasion, stromal invasion and proliferation, and immune response modulation. Finally, we review the prospects for targeting the IL-6 pathway in the trea","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-02T22:47:11.643Z","creation":"2026-04-21T03:14:43.663Z"},"accession":"S-EPMC11061933","cross_references":{"pubmed":["38689325"],"doi":["10.1186/s12967-024-05205-8"]}}