biostudies-literatureDadgar NNHLBI NIH HHSNCI NIH HHSA Glimmer of Hope402https://www.ebi.ac.uk/biostudies/studies/S-EPMC11061933biostudies-literatureUnknown22(1)Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work identifying high concentrations of the cytokine interleukin-6 (IL-6) and its soluble receptor (sIL-6-Rα) in the peritoneal cavity of patients with PC has highlighted this pathway as an emerging potential therapeutic target. This review article provides a comprehensive overview of the current understanding of the potential role of IL-6 in the development and progression of PC. We discuss mechansims by which the IL-6 pathway may contribute to peritoneal tumor dissemination, mesothelial adhesion and invasion, stromal invasion and proliferation, and immune response modulation. Finally, we review the prospects for targeting the IL-6 pathway in the treaJournal of translational medicineTargeting interleukin-6 as a treatment approach for peritoneal carcinomatosis.PMC11061933T32 HL160526R37 CA232209R01 CA114246A Glimmer of HopeWagner PLDonnenberg VPark HSherry CZaidi AHFan YDadgar NXiao KBartlett DLewis CZimmerman JDonnenberg AfalseTargeting interleukin-6 as a treatment approach for peritoneal carcinomatosis.Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work identifying high concentrations of the cytokine interleukin-6 (IL-6) and its soluble receptor (sIL-6-Rα) in the peritoneal cavity of patients with PC has highlighted this pathway as an emerging potential therapeutic target. This review article provides a comprehensive overview of the current understanding of the potential role of IL-6 in the development and progression of PC. We discuss mechansims by which the IL-6 pathway may contribute to peritoneal tumor dissemination, mesothelial adhesion and invasion, stromal invasion and proliferation, and immune response modulation. Finally, we review the prospects for targeting the IL-6 pathway in the trea2024-01-01T00:00:00Z2024 Apr2026-06-02T22:47:11.643Z2026-04-21T03:14:43.663ZS-EPMC110619333868932510.1186/s12967-024-05205-8