{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pallan PS"],"funding":["NCRR NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS","NIH HHS"],"pagination":["2854-2867"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11062489"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(19)"],"pubmed_abstract":["Several efforts are currently directed at the creation and cellular implementation of alternative genetic systems composed of pairing components that are orthogonal to the natural dA/dT and dG/dC base pairs. In an alternative approach, Watson-Crick-type pairing is conserved, but one or all of the four letters of the A, C, G, and T alphabet are substituted by modified components. Thus, all four nucleobases were altered to create halogenated deazanucleic acid (DZA): dA was replaced by 7-deaza-2'-deoxyadenosine (dzA), dG by 7-deaza-2'-deoxyguanosine (dzG), dC by 5-fluoro-2'-deoxycytidine (FdC), and dT by 5-chloro-2'-deoxyuridine (CldU). This base-pairing system was previously shown to retain function in <i>Escherichia coli</i>. Here, we analyze the stability, hydration, structure, and dynamic"],"journal":["Biochemistry"],"pubmed_title":["Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry."],"pmcid":["PMC11062489"],"funding_grant_id":["R35 GM130207","S10 OD020154","GM130207","S10 RR031634"],"pubmed_authors":["Egli M","Lybrand TP","Schepers G","Abramov M","Herdewijn P","Eremeeva E","Rozners E","Pallan PS"],"additional_accession":[]},"is_claimable":false,"name":"Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.","description":"Several efforts are currently directed at the creation and cellular implementation of alternative genetic systems composed of pairing components that are orthogonal to the natural dA/dT and dG/dC base pairs. In an alternative approach, Watson-Crick-type pairing is conserved, but one or all of the four letters of the A, C, G, and T alphabet are substituted by modified components. Thus, all four nucleobases were altered to create halogenated deazanucleic acid (DZA): dA was replaced by 7-deaza-2'-deoxyadenosine (dzA), dG by 7-deaza-2'-deoxyguanosine (dzG), dC by 5-fluoro-2'-deoxycytidine (FdC), and dT by 5-chloro-2'-deoxyuridine (CldU). This base-pairing system was previously shown to retain function in <i>Escherichia coli</i>. Here, we analyze the stability, hydration, structure, and dynamic","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-06-01T09:08:10.716Z","creation":"2025-04-06T16:08:30.186Z"},"accession":"S-EPMC11062489","cross_references":{"pubmed":["37694722"],"doi":["10.1021/acs.biochem.3c00327"]}}