{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Lamas-Paz A"],"funding":["Wellcome Trust"],"pubmed_abstract":["<h4>Background</h4>Alcohol misuse, binge drinking pattern, and gender-specific effects in the middle-aged population has been clearly underestimated. In the present study, we focused on understanding gender-specific effects of alcohol exposure on the gut-liver axis and the role of gut microbiota in modulating gender-specific responses to alcohol consumption.<h4>Methods</h4>Fifty-two-week-old female and male C57BL/6 mice were fasted for 12 h, and then administered a single oral dose of ethanol (EtOH) (6 g/kg). Controls were given a single dose of PBS. Animals were sacrificed 8 h later. Alternatively, fecal microbiota transplantation (FMT) was performed in 52-week-old male mice from female donors of the same age. Permeability of the large intestine (colon), gut microbiota, liver injury, and "],"journal":["Frontiers in nutrition"],"pagination":["1393014"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11063254"],"repository":["biostudies-literature"],"pubmed_title":["Fecal microbiota transplantation from female donors restores gut permeability and reduces liver injury and inflammation in middle-aged male mice exposed to alcohol."],"pmcid":["PMC11063254"],"pubmed_authors":["Gutierrez AH","Banares R","Roa S","Mesquita M","Vaquero J","Benede-Ubieto R","Estevez-Vazquez O","Wu H","Garcia-Lacarte M","Leal Lasalle H","Jorquera G","Martinez-Naves E","Cubero FJ","Nevzorova YA","Lamas-Paz A"],"additional_accession":[]},"is_claimable":false,"name":"Fecal microbiota transplantation from female donors restores gut permeability and reduces liver injury and inflammation in middle-aged male mice exposed to alcohol.","description":"<h4>Background</h4>Alcohol misuse, binge drinking pattern, and gender-specific effects in the middle-aged population has been clearly underestimated. In the present study, we focused on understanding gender-specific effects of alcohol exposure on the gut-liver axis and the role of gut microbiota in modulating gender-specific responses to alcohol consumption.<h4>Methods</h4>Fifty-two-week-old female and male C57BL/6 mice were fasted for 12 h, and then administered a single oral dose of ethanol (EtOH) (6 g/kg). Controls were given a single dose of PBS. Animals were sacrificed 8 h later. Alternatively, fecal microbiota transplantation (FMT) was performed in 52-week-old male mice from female donors of the same age. Permeability of the large intestine (colon), gut microbiota, liver injury, and ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-05-26T20:06:16.116Z","creation":"2026-05-26T03:07:07.403Z"},"accession":"S-EPMC11063254","cross_references":{"pubmed":["38699545"],"doi":["10.3389/fnut.2024.1393014"]}}