{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Du M"],"pubmed_abstract":["<b>Background:</b> Dormant ribosomes are typically associated with preservation factors to protect themselves from degradation under stress conditions. Stm1/SERBP1 is one such protein that anchors the 40S and 60S subunits together. Several proteins and tRNAs bind to this complex as well, yet the molecular mechanisms remain unclear. <b>Methods:</b> Here, we reported the cryo-EM structures of five newly identified Stm1/SERBP1-bound ribosomes. <b>Results:</b> These structures highlighted that eIF5A, eEF2, and tRNA might bind to dormant ribosomes under stress to avoid their own degradation, thus facilitating protein synthesis upon the restoration of growth conditions. In addition, Ribo-seq data analysis reflected the upregulation of nutrient, metabolism, and external-stimulus-related pathways "],"journal":["Frontiers in molecular biosciences"],"pagination":["1395220"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11063288"],"repository":["biostudies-literature"],"pubmed_title":["Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes."],"pmcid":["PMC11063288"],"pubmed_authors":["Li X","Dong W","Zeng F","Du M"],"additional_accession":[]},"is_claimable":false,"name":"Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes.","description":"<b>Background:</b> Dormant ribosomes are typically associated with preservation factors to protect themselves from degradation under stress conditions. Stm1/SERBP1 is one such protein that anchors the 40S and 60S subunits together. Several proteins and tRNAs bind to this complex as well, yet the molecular mechanisms remain unclear. <b>Methods:</b> Here, we reported the cryo-EM structures of five newly identified Stm1/SERBP1-bound ribosomes. <b>Results:</b> These structures highlighted that eIF5A, eEF2, and tRNA might bind to dormant ribosomes under stress to avoid their own degradation, thus facilitating protein synthesis upon the restoration of growth conditions. In addition, Ribo-seq data analysis reflected the upregulation of nutrient, metabolism, and external-stimulus-related pathways ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-05-26T20:05:16.101Z","creation":"2026-05-26T03:07:05.976Z"},"accession":"S-EPMC11063288","cross_references":{"pubmed":["38698775"],"doi":["10.3389/fmolb.2024.1395220"]}}