{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kuzmin E"],"funding":["Cancer Research UK","Worldwide Cancer Research","UKRI Medical Research Council","CPRIT","The Francis Crick Institute","NCI NIH HHS","Ontario Genomics Institute","Wellcome Trust","Genome Canada","Canadian Institutes of Health Research"],"pagination":["113988"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11063629"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(4)"],"pubmed_abstract":["The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. Analysis of The Cancer Genome Atlas data shows recurrent deletion of chr4p in basal breast cancer. Phylogenetic analysis of a panel of 23 primary tumor/patient-derived xenograft basal breast cancers reveals early evolution of chr4p deletion. Mechanistically we show that chr4p loss is associated with enhanced proliferation. Gene function studies identify an unknown gene, C4orf19, within chr4p, which suppresses proliferation when overexpressed-a member of the PDCD10-GCKIII kinase module we name PGCKA1. Genome-wide pooled overexpression screens using a barc"],"journal":["Cell reports"],"pubmed_title":["Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring."],"pmcid":["PMC11063629"],"funding_grant_id":["P30 CA008748","16-0402","CC2008"],"pubmed_authors":["Barber J","Baker TM","Van Loo P","Zou D","Monlong J","Morris Q","Kuzmin E","Kleinman CL","Guiot MC","Morin G","Bourgey M","Omeroglu A","Pacis A","Davison PG","Kuasne H","Park M","Bourque G","Schwartz M","Li R","Fortier AM","Lesluyes T","Ragoussis J","Huang S","Yang Y","Abe KT","Martinez C","Coelho PP","Del Corpo J","Gingras AC"],"additional_accession":[]},"is_claimable":false,"name":"Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring.","description":"The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. Analysis of The Cancer Genome Atlas data shows recurrent deletion of chr4p in basal breast cancer. Phylogenetic analysis of a panel of 23 primary tumor/patient-derived xenograft basal breast cancers reveals early evolution of chr4p deletion. Mechanistically we show that chr4p loss is associated with enhanced proliferation. Gene function studies identify an unknown gene, C4orf19, within chr4p, which suppresses proliferation when overexpressed-a member of the PDCD10-GCKIII kinase module we name PGCKA1. Genome-wide pooled overexpression screens using a barc","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-03T05:08:24.901Z","creation":"2026-04-24T03:14:50.231Z"},"accession":"S-EPMC11063629","cross_references":{"pubmed":["38517886"],"doi":["10.1016/j.celrep.2024.113988"]}}