{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng TL"],"funding":["Government of Malaysia Ministry of Higher Education"],"pagination":["e29785"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11064076"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(9)"],"pubmed_abstract":["Bats are a significant reservoir for numerous pathogens, including <i>Bartonella</i> spp. It is one of the emerging zoonotic bacterial diseases that can be transmitted to humans and may cause various unspecific clinical manifestations. Thus, bartonellosis is rarely diagnosed and is regarded as a neglected vector-borne disease (VBD). Bat flies have been hypothesised to be a vector in the transmission of pathogens among bats. They are host-specific, which reduces the likelihood of pathogen transmission across bat species; however, they are likely to maintain high pathogen loads within their host species. To explore the presence of <i>Bartonella</i> spp. in bat flies from Peninsular Malaysia; bat fly samples collected from various sites at the east coast states were subjected to molecular detection for <i>Bartonella</i> spp. It was discovered that 38.7 % of bats from Terengganu and Kelantan were infested with bat flies; however, no bat fly was found in bats collected from Pahang. The collected bat flies belonged to the families Nycteribiidae (79.6 %) and Streblidae (20.4 %). The collected bat flies were pooled according to the locations and species into 39 pools. Out of these 39 pools, 66.7 % (n = 26) were positive for <i>Bartonella</i> spp. by PCR. Sequence analyses of five randomly selected PCR-positive pools revealed that pools from Kelantan (n = 3) have the closest sequence identities (99 %) to <i>Bartonella</i> spp. strain Lisso-Nig-922 from Nigeria. However, the other pools from Terengganu (n = 2) were closely related to <i>Bartonella</i> spp. strain KP277 from Thailand and <i>Bartonella</i> spp. strain Rhin-3 from the Republic of Georgia with 99 % and 100 % sequence identity, respectively. This suggests that the <i>Bartonella</i> spp. found in Malaysian bat flies are genetically diverse and can potentially serve as reservoirs for pathogenic <i>Bartonella</i> spp."],"journal":["Heliyon"],"pubmed_title":["Molecular prevalence of <i>Bartonella</i> spp. in bat flies in east coast Malaysia."],"pmcid":["PMC11064076"],"funding_grant_id":["TIDREC-2023","MO002-2019"],"pubmed_authors":["C W Zalati CWS","Peng TL","Samoh A","Gilbert B","Loong SK","Mohd Sani NI","Mohamed M","Kamar AH","Hamdan RH"],"additional_accession":[]},"is_claimable":false,"name":"Molecular prevalence of <i>Bartonella</i> spp. in bat flies in east coast Malaysia.","description":"Bats are a significant reservoir for numerous pathogens, including <i>Bartonella</i> spp. It is one of the emerging zoonotic bacterial diseases that can be transmitted to humans and may cause various unspecific clinical manifestations. Thus, bartonellosis is rarely diagnosed and is regarded as a neglected vector-borne disease (VBD). Bat flies have been hypothesised to be a vector in the transmission of pathogens among bats. They are host-specific, which reduces the likelihood of pathogen transmission across bat species; however, they are likely to maintain high pathogen loads within their host species. To explore the presence of <i>Bartonella</i> spp. in bat flies from Peninsular Malaysia; bat fly samples collected from various sites at the east coast states were subjected to molecular detection for <i>Bartonella</i> spp. It was discovered that 38.7 % of bats from Terengganu and Kelantan were infested with bat flies; however, no bat fly was found in bats collected from Pahang. The collected bat flies belonged to the families Nycteribiidae (79.6 %) and Streblidae (20.4 %). The collected bat flies were pooled according to the locations and species into 39 pools. Out of these 39 pools, 66.7 % (n = 26) were positive for <i>Bartonella</i> spp. by PCR. Sequence analyses of five randomly selected PCR-positive pools revealed that pools from Kelantan (n = 3) have the closest sequence identities (99 %) to <i>Bartonella</i> spp. strain Lisso-Nig-922 from Nigeria. However, the other pools from Terengganu (n = 2) were closely related to <i>Bartonella</i> spp. strain KP277 from Thailand and <i>Bartonella</i> spp. strain Rhin-3 from the Republic of Georgia with 99 % and 100 % sequence identity, respectively. This suggests that the <i>Bartonella</i> spp. found in Malaysian bat flies are genetically diverse and can potentially serve as reservoirs for pathogenic <i>Bartonella</i> spp.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T09:15:37.071Z","creation":"2026-04-08T11:01:28.477Z"},"accession":"S-EPMC11064076","cross_references":{"pubmed":["38699006"],"doi":["10.1016/j.heliyon.2024.e29785"]}}