{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(10)"],"submitter":["Yan M"],"pubmed_abstract":["<b>Background:</b> Telomere maintenance takes part in the regulation of gastric cancer (GC) pathogenesis and is essential for patients' clinical features. Though the correlation between a single telomere maintenance-related gene and GC has previously been published, comprehensive exploration and systematic analysis remain to be studied. Our study is aimed at determining telomere maintenance-related molecular subtypes and examining their role in GC. <b>Methods:</b> By analyzing the transcriptome data, we identified three telomere maintenance-associated clusters (TMCs) with heterogeneity in clinical features and tumor microenvironment (TME). Then, we screened five prognostic telomere maintenance-related genes and established corresponding TM scores. Additionally, the expression level and bio"],"journal":["Journal of Cancer"],"pagination":["3227-3241"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11064253"],"repository":["biostudies-literature"],"pubmed_title":["Cross-talk of Three Molecular Subtypes of Telomere Maintenance Defines Clinical Characteristics and Tumor Microenvironment in Gastric Cancer."],"pmcid":["PMC11064253"],"pubmed_authors":["Yan M","Li Z","Zhang Z","Huang H","Wang J","Xu Z","Wang L","Zhu C"],"additional_accession":[]},"is_claimable":false,"name":"Cross-talk of Three Molecular Subtypes of Telomere Maintenance Defines Clinical Characteristics and Tumor Microenvironment in Gastric Cancer.","description":"<b>Background:</b> Telomere maintenance takes part in the regulation of gastric cancer (GC) pathogenesis and is essential for patients' clinical features. Though the correlation between a single telomere maintenance-related gene and GC has previously been published, comprehensive exploration and systematic analysis remain to be studied. Our study is aimed at determining telomere maintenance-related molecular subtypes and examining their role in GC. <b>Methods:</b> By analyzing the transcriptome data, we identified three telomere maintenance-associated clusters (TMCs) with heterogeneity in clinical features and tumor microenvironment (TME). Then, we screened five prognostic telomere maintenance-related genes and established corresponding TM scores. Additionally, the expression level and bio","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-04-24T03:12:09.883Z","creation":"2026-04-24T03:09:12.694Z"},"accession":"S-EPMC11064253","cross_references":{"pubmed":["38706908"],"doi":["10.7150/jca.92207"]}}