{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arabi YM"],"funding":["King Abdullah International Medical Research Center","Novo Nordisk Fonden"],"pagination":["296"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11064302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["Background
The optimal amount and timing of protein intake in critically ill patients are unknown. REPLENISH (Replacing Protein via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients) trial evaluates whether supplemental enteral protein added to standard enteral nutrition to achieve a high amount of enteral protein given from ICU day five until ICU discharge or ICU day 90 as compared to no supplemental enteral protein to achieve a moderate amount of enteral protein would reduce all-cause 90-day mortality in adult critically ill mechanically ventilated patients.Methods
In this multicenter randomized trial, critically ill patients will be randomized to receive supplemental enteral protein (1.2 g/kg/day) added to standard enteral nutrition to achieve a high am"],"journal":["Trials"],"pubmed_title":["Statistical analysis plan for the replacing protein via enteral nutrition in a stepwise approach in critically ill patients (REPLENISH) randomized clinical trial."],"pmcid":["PMC11064302"],"funding_grant_id":["NNF19OC0054863"],"pubmed_authors":["Kharaba A","Khan HB","Maghrabi K","Albalawi S","Preiser JC","Alshahrani MS","and the Saudi Critical Care Trials Group","Junid M","Ansing ML","AlGhamdi K","Alqahtani R","Alodat MA","Al Zayer S","Alerw A","AlGhamdi A","Al-Dawood A","Bcuizon B","AlBakhiet N","Alamoudi S","Alghethamy H","Alabbas SF","Albrahim T","Shobragi K","Al-Dorzi HM","Nouri ST","Almaani M","AlEnezi M","Azhar AO","Baguisa K","Muharib D","Hejazi MM","Alfilfil WA","AlHumaid M","Al-Fares AA","Chalabi J","Atiq R","Ghazi AM","Hussein M","Alfilfil WAM","Anaud CJ","Almekhlafi GA","Al-Hameed F","AlMubarak JH","AlQahtani S","Bashir S","Starkopf J","AlHumedi HI","Idrees K","Lhmdi MH","Jose J","Sakkijha MH","Al Qahtani N","Hefni L","Elghannam MF","Asaas S","Sadat M","Mhawisg H","Qureshi AS","Nuzhat S","Almatroud A","Arabi YM","Otaif Y","Alaskar AS","Asonto LP","Baji O","Johani K","Aldibaasi O","AlOrabi O","AlHusseini A","AlHejiely YA","Baaziz ST","AlOtaibi M","Sifaoui K","Al Bshabshe A","Varela A","Alshayeh R","Mady A","Arishi H","Buabbas SF","Alamrey NK","Rasool G","Boudrar I","Naidu B","Hakami O","Quadri A","Alkraidees AF","AlAnezi B","Malabari R","Farhan K","Burrow V","AlAqeely M","Gabr M","AlZahrani MM","Alahmadi M","Bin Mabkoot M","Perner A","AlDammad M","Al-Mutawa A","Hazem WM","Yusef M","Huma R","Khan L","Algethamy H","AlHarthi A","Alhutail RH"],"additional_accession":[]},"is_claimable":false,"name":"Statistical analysis plan for the replacing protein via enteral nutrition in a stepwise approach in critically ill patients (REPLENISH) randomized clinical trial.","description":"Background
The optimal amount and timing of protein intake in critically ill patients are unknown. REPLENISH (Replacing Protein via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients) trial evaluates whether supplemental enteral protein added to standard enteral nutrition to achieve a high amount of enteral protein given from ICU day five until ICU discharge or ICU day 90 as compared to no supplemental enteral protein to achieve a moderate amount of enteral protein would reduce all-cause 90-day mortality in adult critically ill mechanically ventilated patients.Methods
In this multicenter randomized trial, critically ill patients will be randomized to receive supplemental enteral protein (1.2 g/kg/day) added to standard enteral nutrition to achieve a high am","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T08:37:07.02Z","creation":"2026-05-26T03:07:03.31Z"},"accession":"S-EPMC11064302","cross_references":{"pubmed":["38698442"],"doi":["10.1186/s13063-024-08105-w"]}}