{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guinn S"],"funding":["Jane and Aatos Erkko Foundation","Relander Foundation","Instrumentariumin Tiedesäätiö","iCAN precision medicine of the Finnish academy","Stand Up to Cancer-Lustgarten","NIH/NCI","Sigrid Juséliuksen Säätiö","Emil Aaltosen Säätiö","Lustgarten Foundation","NCI NIH HHS","Hopper-Belmont Foundation","Stand Up To Cancer - Lustgarten"],"pagination":["1517-1533"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11065624"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["84(9)"],"pubmed_abstract":["Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by an immunosuppressive tumor microenvironment enriched with cancer-associated fibroblasts (CAF). This study used a convergence approach to identify tumor cell and CAF interactions through the integration of single-cell data from human tumors with human organoid coculture experiments. Analysis of a comprehensive atlas of PDAC single-cell RNA sequencing data indicated that CAF density is associated with increased inflammation and epithelial-mesenchymal transition (EMT) in epithelial cells. Transfer learning using transcriptional data from patient-derived organoid and CAF cocultures provided in silico validation of CAF induction of inflammatory and EMT epithelial cell states. Further experimental validation in "],"journal":["Cancer research"],"pubmed_title":["Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma."],"pmcid":["PMC11065624"],"funding_grant_id":["P01 CA247886","P30 CA006973","P30CA006973","K08 CA248710","P01CA247886","2015-002","SU2C-AACR-DT26-17","R50 CA243627","F31 CA284525","U01CA253403","U01 CA253403"],"pubmed_authors":["Elisseeff JH","Mitchell JT","Sidiropoulos DN","Loth M","Stein-O'Brien G","Yu J","Danilova L","Seppala TT","Cherry C","Jaffee EM","Gupta A","Kartalia E","Zlomke H","Tandurella JA","Zheng L","Ting DT","Wood LD","Ryan DP","Fertig EJ","Patel J","Kagohara LT","Zabransky DJ","Suri R","He J","Kimmelman A","Wolfgang CL","Kinny-Koster B","Lyman MR","Ramani M","Lee JW","Burkhart RA","Guinn S","Pucsek AB","Zimmerman JW"],"additional_accession":[]},"is_claimable":false,"name":"Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma.","description":"Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by an immunosuppressive tumor microenvironment enriched with cancer-associated fibroblasts (CAF). This study used a convergence approach to identify tumor cell and CAF interactions through the integration of single-cell data from human tumors with human organoid coculture experiments. Analysis of a comprehensive atlas of PDAC single-cell RNA sequencing data indicated that CAF density is associated with increased inflammation and epithelial-mesenchymal transition (EMT) in epithelial cells. Transfer learning using transcriptional data from patient-derived organoid and CAF cocultures provided in silico validation of CAF induction of inflammatory and EMT epithelial cell states. Further experimental validation in ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T06:20:37.979Z","creation":"2025-04-04T09:58:35.352Z"},"accession":"S-EPMC11065624","cross_references":{"pubmed":["38587552"],"doi":["10.1158/0008-5472.can-23-1660","10.1158/0008-5472.CAN-23-1660"]}}