{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alvarez-Martinez M"],"funding":["Cancer Research UK","Medical Research Council","The Francis Crick Institute","&quot;la Caixa&quot; Foundation","Wellcome Trust"],"pagination":["886-901"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11065689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(5)"],"pubmed_abstract":["Intestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified CD4<sup>+</sup> T cells to show that the transcription factors Blimp-1 (encoded by Prdm1) and c-Maf co-dominantly regulate Il10 while negatively regulating proinflammatory cytokines in effector T cells. Double-deficient Prdm1<sup>fl/fl</sup>Maf<sup>fl/fl</sup>Cd4<sup>Cre</sup> mice infected with Helicobacter hepaticus developed severe colitis with an increase in T<sub>H</sub>1/NK/ILC1 effector genes in LPLs, while Prdm1<sup>fl/fl</sup>Cd4<sup>Cre</sup> and Maf<sup>fl/fl</sup>Cd4<sup>Cre</sup> mice exhibited moderate pathology and a less-marked type 1 effector resp"],"journal":["Nature immunology"],"pubmed_title":["Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis."],"pmcid":["PMC11065689"],"funding_grant_id":["CC2032","CC1061","FC001126"],"pubmed_authors":["Pearson CF","Slawinski H","Samelis VA","Chakravarty P","Al-Dibouni A","Powrie F","Alvarez-Martinez M","Briscoe J","Suarez-Bonnet A","Priestnall SL","O'Garra A","Mikolajczak A","Cox LS","Branchett WJ","Gabrysova L","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis.","description":"Intestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified CD4<sup>+</sup> T cells to show that the transcription factors Blimp-1 (encoded by Prdm1) and c-Maf co-dominantly regulate Il10 while negatively regulating proinflammatory cytokines in effector T cells. Double-deficient Prdm1<sup>fl/fl</sup>Maf<sup>fl/fl</sup>Cd4<sup>Cre</sup> mice infected with Helicobacter hepaticus developed severe colitis with an increase in T<sub>H</sub>1/NK/ILC1 effector genes in LPLs, while Prdm1<sup>fl/fl</sup>Cd4<sup>Cre</sup> and Maf<sup>fl/fl</sup>Cd4<sup>Cre</sup> mice exhibited moderate pathology and a less-marked type 1 effector resp","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T21:20:52.867Z","creation":"2026-05-21T03:08:19.217Z"},"accession":"S-EPMC11065689","cross_references":{"pubmed":["38609547"],"doi":["10.1038/s41590-024-01814-z"]}}