{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sammut SJ"],"funding":["European Research Council","Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust","Academy of Medical Sciences"],"pagination":["916-924"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11065701"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(5)"],"pubmed_abstract":["B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance is less well explored. Here we show an integrative analysis of the B cell and T cell receptor repertoire from individuals with metastatic breast cancer and individuals with early breast cancer during neoadjuvant therapy. Using immune receptor, RNA and whole-exome sequencing, we show that both B cell and T cell responses seem to coevolve with the metastatic cancer genomes and mirror tumor mutational and neoantigen architecture. B cell clones associated with metastatic immunosurveillance and temporal persistence were more expanded and distinct from site-specific clones"],"journal":["Nature immunology"],"pubmed_title":["Predictability of B cell clonal persistence and immunosurveillance in breast cancer."],"pmcid":["PMC11065701"],"funding_grant_id":["694620","MC_UU_00002/16","SGL028\\1074","NF-SI-0515-10090","CL-2021-13-002"],"pubmed_authors":["Schatzle S","Galson JD","De Mattos-Arruda L","Sammut SJ","Sun B","Seoane J","Caldas C","Finch DK","Minter R","Osbourn J","Bashford-Rogers RJM","Chin SF","Dias J","Rueda OM"],"additional_accession":[]},"is_claimable":false,"name":"Predictability of B cell clonal persistence and immunosurveillance in breast cancer.","description":"B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance is less well explored. Here we show an integrative analysis of the B cell and T cell receptor repertoire from individuals with metastatic breast cancer and individuals with early breast cancer during neoadjuvant therapy. Using immune receptor, RNA and whole-exome sequencing, we show that both B cell and T cell responses seem to coevolve with the metastatic cancer genomes and mirror tumor mutational and neoantigen architecture. B cell clones associated with metastatic immunosurveillance and temporal persistence were more expanded and distinct from site-specific clones","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T05:37:14.656Z","creation":"2026-04-08T09:39:51.985Z"},"accession":"S-EPMC11065701","cross_references":{"pubmed":["38698238"],"doi":["10.1038/s41590-024-01821-0"]}}