biostudies-literatureSammut SJEuropean Research CouncilMedical Research CouncilNational Institute for Health Research (NIHR)Wellcome TrustAcademy of Medical Sciences916-924https://www.ebi.ac.uk/biostudies/studies/S-EPMC11065701biostudies-literatureUnknown25(5)B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance is less well explored. Here we show an integrative analysis of the B cell and T cell receptor repertoire from individuals with metastatic breast cancer and individuals with early breast cancer during neoadjuvant therapy. Using immune receptor, RNA and whole-exome sequencing, we show that both B cell and T cell responses seem to coevolve with the metastatic cancer genomes and mirror tumor mutational and neoantigen architecture. B cell clones associated with metastatic immunosurveillance and temporal persistence were more expanded and distinct from site-specific clonesNature immunologyPredictability of B cell clonal persistence and immunosurveillance in breast cancer.PMC11065701694620MC_UU_00002/16SGL028\1074NF-SI-0515-10090CL-2021-13-002Schatzle SGalson JDDe Mattos-Arruda LSammut SJSun BSeoane JCaldas CFinch DKMinter ROsbourn JBashford-Rogers RJMChin SFDias JRueda OMfalsePredictability of B cell clonal persistence and immunosurveillance in breast cancer.B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance is less well explored. Here we show an integrative analysis of the B cell and T cell receptor repertoire from individuals with metastatic breast cancer and individuals with early breast cancer during neoadjuvant therapy. Using immune receptor, RNA and whole-exome sequencing, we show that both B cell and T cell responses seem to coevolve with the metastatic cancer genomes and mirror tumor mutational and neoantigen architecture. B cell clones associated with metastatic immunosurveillance and temporal persistence were more expanded and distinct from site-specific clones2024-01-01T00:00:00Z2024 May2026-06-01T05:37:14.656Z2026-04-08T09:39:51.985ZS-EPMC110657013869823810.1038/s41590-024-01821-0