{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(5)"],"submitter":["Iibushi J"],"funding":["Kyoto University"],"pubmed_abstract":["Invasive bacterial pathogens are internalized by host cells through endocytosis, which is regulated by a cascade of actin rearrangement signals triggered by host cell receptors or bacterial proteins delivered into host cells. However, the molecular mechanisms that mediate actin rearrangement to promote bacterial invasion are not fully understood. Here, we show that the autophagy-related (ATG) protein ATG9B regulates the internalization of various bacteria by controlling actin rearrangement. <i>ATG</i> knockout screening and knockdown experiments in HeLa cells identified ATG9B as a critical factor for bacterial internalization. In particular, cells with <i>ATG9B</i> knockdown exhibited an accumulation of actin filaments and phosphorylated LIM kinase and cofilin, suggesting that ATG9B is inv"],"journal":["iScience"],"pagination":["109623"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11066431"],"repository":["biostudies-literature"],"pubmed_title":["ATG9B regulates bacterial internalization via actin rearrangement."],"pmcid":["PMC11066431"],"pubmed_authors":["Iibushi J","Toh H","Nozawa T","Nakagawa I"],"additional_accession":[]},"is_claimable":false,"name":"ATG9B regulates bacterial internalization via actin rearrangement.","description":"Invasive bacterial pathogens are internalized by host cells through endocytosis, which is regulated by a cascade of actin rearrangement signals triggered by host cell receptors or bacterial proteins delivered into host cells. However, the molecular mechanisms that mediate actin rearrangement to promote bacterial invasion are not fully understood. Here, we show that the autophagy-related (ATG) protein ATG9B regulates the internalization of various bacteria by controlling actin rearrangement. <i>ATG</i> knockout screening and knockdown experiments in HeLa cells identified ATG9B as a critical factor for bacterial internalization. In particular, cells with <i>ATG9B</i> knockdown exhibited an accumulation of actin filaments and phosphorylated LIM kinase and cofilin, suggesting that ATG9B is inv","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-05-26T20:06:21.915Z","creation":"2026-05-26T03:07:08.078Z"},"accession":"S-EPMC11066431","cross_references":{"pubmed":["38706859"],"doi":["10.1016/j.isci.2024.109623"]}}