{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(5)"],"submitter":["Dottermusch M"],"funding":["Deutsche Forschungsgemeinschaft","Erich und Gertrud Roggenbuck-Stiftung","Fördergemeinschaft Kinderkrebszentrum Hamburg","Hamburger Krebsgesellschaft e.V."],"pubmed_abstract":["<h4>Background</h4>Embryonal tumors with multilayered rosettes (ETMR) are rare malignant embryonal brain tumors. The prognosis of ETMR is poor and novel therapeutic approaches are desperately needed. Comprehension of ETMR tumor biology is currently based on only few previous molecular studies, which mainly focused on the analyses of nucleic acids. In this study, we explored integrated ETMR proteomics.<h4>Methods</h4>Using mass spectrometry, proteome data were acquired from 16 ETMR and the ETMR cell line BT183. Proteome data were integrated with case-matched global DNA methylation data, publicly available transcriptome data, and proteome data of further embryonal and pediatric brain tumors.<h4>Results</h4>Proteome-based cluster analyses grouped ETMR samples according to histomorphology, sep"],"journal":["Neuro-oncology"],"pagination":["935-949"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11066909"],"repository":["biostudies-literature"],"pubmed_title":["Integrated proteomics spotlight the proteasome as a therapeutic vulnerability in embryonal tumors with multilayered rosettes."],"pmcid":["PMC11066909"],"pubmed_authors":["Frank S","Godbole S","Schumann Y","Schluter H","Biabani A","Dottermusch M","Obrecht D","Dorostkar MM","Schuller U","Navolic J","Lempertz T","Neumann JE","Voß H","Rutkowski S"],"additional_accession":[]},"is_claimable":false,"name":"Integrated proteomics spotlight the proteasome as a therapeutic vulnerability in embryonal tumors with multilayered rosettes.","description":"<h4>Background</h4>Embryonal tumors with multilayered rosettes (ETMR) are rare malignant embryonal brain tumors. The prognosis of ETMR is poor and novel therapeutic approaches are desperately needed. Comprehension of ETMR tumor biology is currently based on only few previous molecular studies, which mainly focused on the analyses of nucleic acids. In this study, we explored integrated ETMR proteomics.<h4>Methods</h4>Using mass spectrometry, proteome data were acquired from 16 ETMR and the ETMR cell line BT183. Proteome data were integrated with case-matched global DNA methylation data, publicly available transcriptome data, and proteome data of further embryonal and pediatric brain tumors.<h4>Results</h4>Proteome-based cluster analyses grouped ETMR samples according to histomorphology, sep","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-13T03:27:57.513Z","creation":"2026-04-13T03:13:00.949Z"},"accession":"S-EPMC11066909","cross_references":{"pubmed":["38158710"],"doi":["10.1093/neuonc/noad265"]}}