{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim D"],"funding":["Ministry of Science","National Research Foundatio"],"pagination":["843-857"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11066945"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(5)"],"pubmed_abstract":["<h4>Background</h4>Reactive astrogliosis is a hallmark of various brain pathologies, including neurodegenerative diseases and glioblastomas. However, the specific intermediate metabolites contributing to reactive astrogliosis remain unknown. This study investigated how glioblastomas induce reactive astrogliosis in the neighboring microenvironment and explore 11C-acetate PET as an imaging technique for detecting reactive astrogliosis.<h4>Methods</h4>Through in vitro, mouse models, and human tissue experiments, we examined the association between elevated 11C-acetate uptake and reactive astrogliosis in gliomas. We explored acetate from glioblastoma cells, which triggers reactive astrogliosis in neighboring astrocytes by upregulating MAO-B and monocarboxylate transporter 1 (MCT1) expression. "],"journal":["Neuro-oncology"],"pubmed_title":["Visualizing cancer-originating acetate uptake through monocarboxylate transporter 1 in reactive astrocytes in the glioblastoma tumor microenvironment."],"pmcid":["PMC11066945"],"funding_grant_id":["NRF-2020R1A2B5B01098109","NRF-2021R1C1C2011016","RS-2022-00144475"],"pubmed_authors":["Kim D","Lee S","Kim SY","Yun M","Kim H","Lee M","Kim J","Kim SH","Park Y","Kang SG","Han KS","Park YM","Chun JH","Park SJ","Park KD","Nam MH","Park J","Ryu H","Ju YH","Chung JI","Park S","Park U","Kim S","Chang JH","Lee SY","Lee CJ","Lim H","Lee GH","Ko HY","Shim JK"],"additional_accession":[]},"is_claimable":false,"name":"Visualizing cancer-originating acetate uptake through monocarboxylate transporter 1 in reactive astrocytes in the glioblastoma tumor microenvironment.","description":"<h4>Background</h4>Reactive astrogliosis is a hallmark of various brain pathologies, including neurodegenerative diseases and glioblastomas. However, the specific intermediate metabolites contributing to reactive astrogliosis remain unknown. This study investigated how glioblastomas induce reactive astrogliosis in the neighboring microenvironment and explore 11C-acetate PET as an imaging technique for detecting reactive astrogliosis.<h4>Methods</h4>Through in vitro, mouse models, and human tissue experiments, we examined the association between elevated 11C-acetate uptake and reactive astrogliosis in gliomas. We explored acetate from glioblastoma cells, which triggers reactive astrogliosis in neighboring astrocytes by upregulating MAO-B and monocarboxylate transporter 1 (MCT1) expression. ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2025-04-26T16:05:12.696Z","creation":"2025-04-06T15:08:29.621Z"},"accession":"S-EPMC11066945","cross_references":{"pubmed":["38085571"],"doi":["10.1093/neuonc/noad243"]}}