biostudies-literatureUnknown29(5)Iannantuono GMNational Cancer InstituteNCI NIH HHSNational Institutes of HealthNIH HHS<h4>Background</h4>The capability of large language models (LLMs) to understand and generate human-readable text has prompted the investigation of their potential as educational and management tools for patients with cancer and healthcare providers.<h4>Materials and methods</h4>We conducted a cross-sectional study aimed at evaluating the ability of ChatGPT-4, ChatGPT-3.5, and Google Bard to answer questions related to 4 domains of immuno-oncology (Mechanisms, Indications, Toxicities, and Prognosis). We generated 60 open-ended questions (15 for each section). Questions were manually submitted to LLMs, and responses were collected on June 30, 2023. Two reviewers evaluated the answers independently.<h4>Results</h4>ChatGPT-4 and ChatGPT-3.5 answered all questions, whereas Google Bard answered The oncologist407-414https://www.ebi.ac.uk/biostudies/studies/S-EPMC11067804biostudies-literatureComparison of Large Language Models in Answering Immuno-Oncology Questions: A Cross-Sectional Study.PMC11067804Choo-Wosoba HBracken-Clarke DGulley JLIannantuono GMFloudas CSKarzai FfalseComparison of Large Language Models in Answering Immuno-Oncology Questions: A Cross-Sectional Study.<h4>Background</h4>The capability of large language models (LLMs) to understand and generate human-readable text has prompted the investigation of their potential as educational and management tools for patients with cancer and healthcare providers.<h4>Materials and methods</h4>We conducted a cross-sectional study aimed at evaluating the ability of ChatGPT-4, ChatGPT-3.5, and Google Bard to answer questions related to 4 domains of immuno-oncology (Mechanisms, Indications, Toxicities, and Prognosis). We generated 60 open-ended questions (15 for each section). Questions were manually submitted to LLMs, and responses were collected on June 30, 2023. Two reviewers evaluated the answers independently.<h4>Results</h4>ChatGPT-4 and ChatGPT-3.5 answered all questions, whereas Google Bard answered 2024-01-01T00:00:00Z2024 May2026-06-03T10:04:15.947Z2026-04-26T03:11:36.948ZS-EPMC110678043830972010.1093/oncolo/oyae009