{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(5)"],"submitter":["Brinkkemper M"],"funding":["Bill & Melinda Gates Foundation"],"pubmed_abstract":["Zoonotic events by sarbecoviruses have sparked an epidemic (severe acute respiratory syndrome coronavirus [SARS-CoV]) and a pandemic (SARS-CoV-2) in the past two decades. The continued risk of spillovers from animals to humans is an ongoing threat to global health and a pan-sarbecovirus vaccine would be an important contribution to pandemic preparedness. Here, we describe multivalent virosome-based vaccines that present stabilized spike proteins from four sarbecovirus strains, one from each clade. A cocktail of four monovalent virosomes or a mosaic virosome preparation induced broad sarbecovirus binding and neutralizing antibody responses in mice. Pre-existing immunity against SARS-CoV-2 and extending the intervals between immunizations enhanced antibody responses. These results should inf"],"journal":["iScience"],"pagination":["109719"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11068555"],"repository":["biostudies-literature"],"pubmed_title":["A spike virosome vaccine induces pan-sarbecovirus antibody responses in mice."],"pmcid":["PMC11068555"],"pubmed_authors":["Poniman M","Sanders RW","Bijl TPL","Bhoelan F","Iddouch WA","Brinkkemper M","van Gils MJ","Guerra D","Siteur-van Rijnstra E","Bemelman D","Kempers R","van der Velden YU","Grobben M","Tejjani K","Stegmann T","Sliepen K"],"additional_accession":[]},"is_claimable":false,"name":"A spike virosome vaccine induces pan-sarbecovirus antibody responses in mice.","description":"Zoonotic events by sarbecoviruses have sparked an epidemic (severe acute respiratory syndrome coronavirus [SARS-CoV]) and a pandemic (SARS-CoV-2) in the past two decades. The continued risk of spillovers from animals to humans is an ongoing threat to global health and a pan-sarbecovirus vaccine would be an important contribution to pandemic preparedness. Here, we describe multivalent virosome-based vaccines that present stabilized spike proteins from four sarbecovirus strains, one from each clade. A cocktail of four monovalent virosomes or a mosaic virosome preparation induced broad sarbecovirus binding and neutralizing antibody responses in mice. Pre-existing immunity against SARS-CoV-2 and extending the intervals between immunizations enhanced antibody responses. These results should inf","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T21:21:01.823Z","creation":"2026-05-21T03:08:21.383Z"},"accession":"S-EPMC11068555","cross_references":{"pubmed":["38706848"],"doi":["10.1016/j.isci.2024.109719"]}}