biostudies-literatureUnknown9(5)Lo Faro MLNHS Blood and Transplant<h4>Introduction</h4>Delayed graft function (DGF) is often defined as the need for dialysis treatment in the first week after a kidney transplantation. This definition, though readily applicable, is generic and unable to distinguish between "types" of DGF or time needed to recover function that may also significantly affect longer-term outcomes. We aimed to profile biological pathways in donation after circulatory death (DCD) kidney donors that correlate with DGF and different DGF durations.<h4>Methods</h4>A total of <i>N</i> = 30 DCD kidney biopsies were selected from the UK Quality in Organ Donation (QUOD) biobank and stratified according to DGF duration (immediate function, IF <i>n</i> = 10; "short-DGF" (1-6 days), SDGF <i>n</i> = 10; "long-DGF" (7-22 days), LDGF <i>n</i> = 10). SamplesKidney international reports1473-1483https://www.ebi.ac.uk/biostudies/studies/S-EPMC11068965biostudies-literatureKidney Tissue Proteome Profiles in Short Versus Long Duration of Delayed Graft Function - A Pilot Study in Donation After Circulatory Death Donors.PMC11068965Rozenberg KSharples EFischer RLindeman JHHuang HMaslau SLo Faro MLBonham SLeuvenink HPloeg RKessler BfalseKidney Tissue Proteome Profiles in Short Versus Long Duration of Delayed Graft Function - A Pilot Study in Donation After Circulatory Death Donors.<h4>Introduction</h4>Delayed graft function (DGF) is often defined as the need for dialysis treatment in the first week after a kidney transplantation. This definition, though readily applicable, is generic and unable to distinguish between "types" of DGF or time needed to recover function that may also significantly affect longer-term outcomes. We aimed to profile biological pathways in donation after circulatory death (DCD) kidney donors that correlate with DGF and different DGF durations.<h4>Methods</h4>A total of <i>N</i> = 30 DCD kidney biopsies were selected from the UK Quality in Organ Donation (QUOD) biobank and stratified according to DGF duration (immediate function, IF <i>n</i> = 10; "short-DGF" (1-6 days), SDGF <i>n</i> = 10; "long-DGF" (7-22 days), LDGF <i>n</i> = 10). Samples2024-01-01T00:00:00Z2024 May2026-06-01T05:37:03.437Z2026-04-08T09:39:04.718ZS-EPMC110689653870780410.1016/j.ekir.2024.02.012