{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Salas AA"],"funding":["NICHD NIH HHS","NCATS NIH HHS","NHLBI NIH HHS"],"pagination":["e249643"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11069076"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(5)"],"pubmed_abstract":["<h4>Importance</h4>Observational studies often report that anemia and red blood cell (RBC) transfusions are associated with a higher risk of necrotizing enterocolitis (NEC) among extremely low-birthweight (ELBW) infants.<h4>Objective</h4>To evaluate whether there is a temporal association between 72-hour hazard periods of exposure to RBC transfusions and NEC among ELBW infants randomized to either higher or lower hemoglobin transfusion thresholds.<h4>Design, setting, and participants</h4>This post hoc secondary analysis of 1690 ELBW infants who survived to postnatal day 10 enrolled in the Transfusion of Prematures (TOP) randomized multicenter trial between December 1, 2012, and April 12, 2017, was performed between June 2021 and July 2023.<h4>Exposures</h4>First, the distribution of RBC tr"],"journal":["JAMA network open"],"pubmed_title":["Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis: A Secondary Analysis of a Randomized Clinical Trial."],"pmcid":["PMC11069076"],"funding_grant_id":["UG1 HD068278","UG1 HD027904","UL1 TR000454","UL1 TR000077","UG1 HD068270","UG1 HD034216","U10 HD027880","UG1 HD027851","UG1 HD027853","U01 HL112776","UG1 HD087226","UG1 HD087229","UG1 HD040492","UL1 TR000042","UG1 HD068244","UL1 TR000041","UG1 HD053109","UG1 HD027856","UG1 HD068263","UL1 TR000442","U01 HD036790","UG1 HD068284","UL1 TR000006","UL1 TR000105","UL1 TR001117","K23 HD102554","U24 HD095254","UG1 HD053089","UG1 HD040689","U01 HL112748","U10 HD021373","UG1 HD021385","UL1 TR000093","UG1 HD021364"],"pubmed_authors":["Huffman LC","Panaitescu B","Bentley A","Petrie Huitema 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CA","Zaterka-Baxter KM","Hunn J","Mago-Shah D","Carter SL","Marzec L","Hanson M","Heyne RJ","Geller R","Smiley L","Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network","Edwards L","Sood BG","Malcolm WF","Smikle G","Cucinotta DM","Prinzing D","White DF","Laptook AR","Maxson E","Scorsone AM","Lucash RE","Carcelen MP","Colaizy TT","Sokol GM","Crawford MM","Lee LE","Christensen S","Hale EC","Chanlaw T","O'Donnel Auman J","D'Angio CT","Collins MV","Sacilowski M","Earhart B","Devaskar U","Barks J","Goldston L","Widness JA","Leblond D","Bell EF","Mondoro TH","Orme C","Gauldin C","Moses MB","Small K","Wilson-Costello DE","Carlton DP","Binion K","Warren M","Parry DM","Schmidt B","Wyckoff MH","Krueger CE","Vasil DM","Bhola M","Hensman AM","Burnett J","Wereszczak J","Fortney CA","Wright SL","Holmes A","Loggins Y","Dudley J","Baserga M","Fearns E","York Chapman S","Mackie C","Vieira E","Comerford LC","Reichert EN","Childs K","Garg M","Nelin MA","Bara R","Carey H","Zorn W","Baugher H","Ohls RK","Chock VY","Tan S","Whyte RK","Shankaran S","Park C","Gantz MG","Rau CA","Yalcinkaya G","Johnston KC","Wadkins HIM","Hall DJ","Mulligan LaRossa M","Laughon MM","Gunn S","Rhodes-Ryan G","Muthig G","Pavageau L","Weaver-Lewis K","Khan AM","Sundquist Beauman S","Merzbach J","Chawla S","vonLehmden A","Bose CL","Maffett D","Grothause J","Chaudhary AS","Domnanovich KA","Eason E","Zupancic JAF","Cole Bledsoe L","McGrath KM","Minton SD","Maitre NL","DeAnda ME","Elmont JO","Gabrio J","Payne AH","Das A","Phillips VA","Mickelsen HG","Fuller J"],"additional_accession":[]},"is_claimable":false,"name":"Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis: A Secondary Analysis of a Randomized Clinical Trial.","description":"<h4>Importance</h4>Observational studies often report that anemia and red blood cell (RBC) transfusions are associated with a higher risk of necrotizing enterocolitis (NEC) among extremely low-birthweight (ELBW) infants.<h4>Objective</h4>To evaluate whether there is a temporal association between 72-hour hazard periods of exposure to RBC transfusions and NEC among ELBW infants randomized to either higher or lower hemoglobin transfusion thresholds.<h4>Design, setting, and participants</h4>This post hoc secondary analysis of 1690 ELBW infants who survived to postnatal day 10 enrolled in the Transfusion of Prematures (TOP) randomized multicenter trial between December 1, 2012, and April 12, 2017, was performed between June 2021 and July 2023.<h4>Exposures</h4>First, the distribution of RBC tr","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T23:44:58.461Z","creation":"2026-05-23T03:08:17.664Z"},"accession":"S-EPMC11069076","cross_references":{"pubmed":["38700862"],"doi":["10.1001/jamanetworkopen.2024.9643"]}}