biostudies-literatureLi YExcellence Program of Shanghai Municipal Health CommissionNatural Science Foundation of ShanghaiShanghai Rising-Star Program356https://www.ebi.ac.uk/biostudies/studies/S-EPMC11069191biostudies-literatureUnknown25(1)<h4>Background</h4>Intervertebral disc degeneration (IVDD) is a common degenerative condition leading to abnormal stress distribution under load, causing intervertebral stenosis, facet joint degeneration, and foraminal stenosis. Very little is known about the molecular mechanism of eRNAs in IVDD.<h4>Methods</h4>Gene expression profiles of 38 annulus disc samples composed of 27 less degenerated discs (LDs) and 11 more degenerated discs (MDs) were retrieved from the GEO database. Then, differentially expressed enhancer RNAs (DEeRNAs), differentially expressed target genes (DETGs), and differentially expressed transcription factors (DETFs), hallmark of cancer signalling pathways according to GSVA; the types and quantity of immune cells according to CIBERSORT; and immune gene sets according toBMC musculoskeletal disordersIdentification of key eRNAs for intervertebral disc degeneration by integrated multinomial bioinformatics analysis.PMC1106919123YF145840022ZR145050020234Z0020Yin HLi YMeng TSong DHan XHuang RYe JfalseIdentification of key eRNAs for intervertebral disc degeneration by integrated multinomial bioinformatics analysis.<h4>Background</h4>Intervertebral disc degeneration (IVDD) is a common degenerative condition leading to abnormal stress distribution under load, causing intervertebral stenosis, facet joint degeneration, and foraminal stenosis. Very little is known about the molecular mechanism of eRNAs in IVDD.<h4>Methods</h4>Gene expression profiles of 38 annulus disc samples composed of 27 less degenerated discs (LDs) and 11 more degenerated discs (MDs) were retrieved from the GEO database. Then, differentially expressed enhancer RNAs (DEeRNAs), differentially expressed target genes (DETGs), and differentially expressed transcription factors (DETFs), hallmark of cancer signalling pathways according to GSVA; the types and quantity of immune cells according to CIBERSORT; and immune gene sets according to2024-01-01T00:00:00Z2024 May2026-07-15T04:50:32.193Z2026-06-29T03:09:49.729ZS-EPMC110691913870451910.1186/s12891-024-07438-6