{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Z"],"funding":["National Key Research and Development Program of China"],"pagination":["41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11070108"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Background
Infections caused by linezolid-resistant enterococci (LRE) are clinically difficult to treat and threaten patient health. However, there is a lack of studies on long time-span LRE strains in China. For this reason, our study comprehensively revealed the resistance mechanisms of LRE strains collected in a Chinese tertiary care hospital from 2011 to 2022.Methods
Enterococcal strains were screened and verified after retrospective analysis of microbial data. Subsequently, 65 LRE strains (61 Enterococcus faecalis and 4 Enterococcus faecium, MIC ≥ 8 µg/ml), 1 linezolid-intermediate Enterococcus faecium (MIC = 4 µg/ml) and 1 linezolid-susceptible Enterococcus faecium (MIC = 1.5 µg/ml) were submitted for whole-genome sequencing (WGS) analysis and bioinformatics analysis."],"journal":["Annals of clinical microbiology and antimicrobials"],"pubmed_title":["Genomic epidemiology reveals multiple mechanisms of linezolid resistance in clinical enterococci in China."],"pmcid":["PMC11070108"],"funding_grant_id":["2021YFF0703805"],"pubmed_authors":["Hu S","Wu L","Liu L","Zhang J","Zhang Z","He Z","Liu C","Liu D","Sun H","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Genomic epidemiology reveals multiple mechanisms of linezolid resistance in clinical enterococci in China.","description":"Background
Infections caused by linezolid-resistant enterococci (LRE) are clinically difficult to treat and threaten patient health. However, there is a lack of studies on long time-span LRE strains in China. For this reason, our study comprehensively revealed the resistance mechanisms of LRE strains collected in a Chinese tertiary care hospital from 2011 to 2022.Methods
Enterococcal strains were screened and verified after retrospective analysis of microbial data. Subsequently, 65 LRE strains (61 Enterococcus faecalis and 4 Enterococcus faecium, MIC ≥ 8 µg/ml), 1 linezolid-intermediate Enterococcus faecium (MIC = 4 µg/ml) and 1 linezolid-susceptible Enterococcus faecium (MIC = 1.5 µg/ml) were submitted for whole-genome sequencing (WGS) analysis and bioinformatics analysis.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-08T15:57:06.88Z","creation":"2026-04-08T05:45:06.248Z"},"accession":"S-EPMC11070108","cross_references":{"pubmed":["38704577"],"doi":["10.1186/s12941-024-00689-0"]}}