{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sponchiado M"],"funding":["NHLBI NIH HHS","NIH HHS"],"pagination":["1392443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11070562"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15"],"pubmed_abstract":["<b>Introduction:</b> Interleukin 13 (IL-13) is an important effector molecule in allergic asthma. IL-13-mediated mucin hypersecretion requires conversion of secretoglobin-positive club cells into goblet cells through suppression of <i>forkhead box A2</i> (<i>FOXA2</i>) and induction of <i>SAM pointed domain containing ETS transcription factor</i> (<i>SPDEF</i>). IL-13-mediated mucin hypersecretion may also include modulation of purinergic and muscarinic receptors that control basal and stimulated mucin secretion. We recently found that the transcription factor cAMP response element-binding protein (Creb1) inhibits <i>FOXA2</i> and modulates mucus secretion in mice. <b>Methods:</b> We tested the hypothesis that loss of club cell Creb1 mitigates the pro-mucin effects of IL-13. We challenged "],"journal":["Frontiers in physiology"],"pubmed_title":["Sex-dependent regulation of mucin gene transcription and airway secretion and mechanics following intra-airway IL-13 in mice with conditional loss of club cell Creb1."],"pmcid":["PMC11070562"],"funding_grant_id":["R01 HL152101","OT2 OD026582"],"pubmed_authors":["Trevizan-Bau P","Sponchiado M","Bonilla AL","Prabhakaran S","Reznikov LR","Fagan A","Mata L"],"additional_accession":[]},"is_claimable":false,"name":"Sex-dependent regulation of mucin gene transcription and airway secretion and mechanics following intra-airway IL-13 in mice with conditional loss of club cell Creb1.","description":"<b>Introduction:</b> Interleukin 13 (IL-13) is an important effector molecule in allergic asthma. IL-13-mediated mucin hypersecretion requires conversion of secretoglobin-positive club cells into goblet cells through suppression of <i>forkhead box A2</i> (<i>FOXA2</i>) and induction of <i>SAM pointed domain containing ETS transcription factor</i> (<i>SPDEF</i>). IL-13-mediated mucin hypersecretion may also include modulation of purinergic and muscarinic receptors that control basal and stimulated mucin secretion. We recently found that the transcription factor cAMP response element-binding protein (Creb1) inhibits <i>FOXA2</i> and modulates mucus secretion in mice. <b>Methods:</b> We tested the hypothesis that loss of club cell Creb1 mitigates the pro-mucin effects of IL-13. We challenged ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T08:04:07.639Z","creation":"2026-04-08T10:48:26.911Z"},"accession":"S-EPMC11070562","cross_references":{"pubmed":["38711951"],"doi":["10.3389/fphys.2024.1392443"]}}