{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["103(7)"],"submitter":["Xu C"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["Stress is known to disrupt the intestinal barrier and induce intestinal dysfunction. A critical role for gonadotropin inhibitory hormone (GnIH) in stress has emerged. However, whether GnIH mediates stress-induced intestinal dysfunction remains unknown. The present study explored this question through in vivo and in vitro experiments in hens. Our in vivo experiments showed that continuous intraperitoneal injection of GnIH not only significantly increased the concentration of stress hormones in serum, but also significantly elevated the mRNA expression of glucocorticoid receptor (GR) in the duodenum and jejunum. Moreover, morphological and molecular analyses revealed that GnIH disrupted the physical and chemical barriers of the intestine and dramatically increased inflammatory factor levels "],"journal":["Poultry science"],"pagination":["103757"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11070904"],"repository":["biostudies-literature"],"pubmed_title":["The possibly role of GnIH in stress and gut dysfunction in chicken."],"pmcid":["PMC11070904"],"pubmed_authors":["Ma R","Zhang J","Xu C","Shen B","Zhang L","Li X","Li Y","Hu C","Li Z","Ji W","Zhang X","Liu C","Wang X","Song X","Han D","Xin Y"],"additional_accession":[]},"is_claimable":false,"name":"The possibly role of GnIH in stress and gut dysfunction in chicken.","description":"Stress is known to disrupt the intestinal barrier and induce intestinal dysfunction. A critical role for gonadotropin inhibitory hormone (GnIH) in stress has emerged. However, whether GnIH mediates stress-induced intestinal dysfunction remains unknown. The present study explored this question through in vivo and in vitro experiments in hens. Our in vivo experiments showed that continuous intraperitoneal injection of GnIH not only significantly increased the concentration of stress hormones in serum, but also significantly elevated the mRNA expression of glucocorticoid receptor (GR) in the duodenum and jejunum. Moreover, morphological and molecular analyses revealed that GnIH disrupted the physical and chemical barriers of the intestine and dramatically increased inflammatory factor levels ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-07-15T09:19:21.752Z","creation":"2025-08-16T03:06:29.183Z"},"accession":"S-EPMC11070904","cross_references":{"pubmed":["38697006"],"doi":["10.1016/j.psj.2024.103757"]}}