{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Afanasyev AY"],"funding":["Directorate for Biological Sciences","Office of Extramural Research, National Institutes of Health","NIGMS NIH HHS"],"pagination":["13"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11071202"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>Multiple studies have demonstrated a negative correlation between gene expression and positioning of genes at the nuclear envelope (NE) lined by nuclear lamina, but the exact relationship remains unclear, especially in light of the highly stochastic, transient nature of the gene association with the NE.<h4>Results</h4>In this paper, we ask whether there is a causal, systematic, genome-wide relationship between the expression levels of the groups of genes in topologically associating domains (TADs) of Drosophila nuclei and the probabilities of TADs to be found at the NE. To investigate the nature of this possible relationship, we combine a coarse-grained dynamic model of the entire Drosophila nucleus with genome-wide gene expression data; we analyze the TAD averaged trans"],"journal":["Epigenetics & chromatin"],"pubmed_title":["The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level in fruit flies."],"pmcid":["PMC11071202"],"funding_grant_id":["GM14459","MCB-1715207","R01 GM144596"],"pubmed_authors":["Onufriev AV","Afanasyev AY","Kim Y","Tolokh IS","Sharakhov IV"],"additional_accession":[]},"is_claimable":false,"name":"The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level in fruit flies.","description":"<h4>Background</h4>Multiple studies have demonstrated a negative correlation between gene expression and positioning of genes at the nuclear envelope (NE) lined by nuclear lamina, but the exact relationship remains unclear, especially in light of the highly stochastic, transient nature of the gene association with the NE.<h4>Results</h4>In this paper, we ask whether there is a causal, systematic, genome-wide relationship between the expression levels of the groups of genes in topologically associating domains (TADs) of Drosophila nuclei and the probabilities of TADs to be found at the NE. To investigate the nature of this possible relationship, we combine a coarse-grained dynamic model of the entire Drosophila nucleus with genome-wide gene expression data; we analyze the TAD averaged trans","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-07-14T21:19:39.033Z","creation":"2026-06-24T03:10:31.558Z"},"accession":"S-EPMC11071202","cross_references":{"pubmed":["38705995"],"doi":["10.1186/s13072-024-00528-8"]}}